Mechanistically, Escargot suppresses insulin receptor (InR) signaling in stem cells to prevent differentiation. InR signaling suppression by Escargot is required for the preservation of stem …

2017年12月12日 · Via LIN-28, FMRP controls progenitor cell behavior by post-transcriptionally repressing the level of Insulin Receptor (InR). This study identifies the stem cell based …

The absence of InR/Pi3K in progenitors leads to a decrease in the number of EBs, while it has no significant effect on intestinal stem cells (ISCs). In addition, we found that InR/Pi3K regulates …

2022年9月7日 · Mechanistically, we show that Imp cooperates and directly interacts with Lin28, another highly conserved RBP, to regulate ISC proliferation. We found that both proteins bind …

In the adult mouse and Drosophila intestine, stem cell homeostasis is achieved via population asymmetry renewal, in which population expansion is matched by loss via differentia-

2015年10月15日 · Immunoprecipitation of Lin-28-bound mRNAs identified Insulin-like Receptor (InR), forced expression of which completely rescues lin-28-associated defects in intestinal …

国际标准化比值（international normalized ratio，INR）是患者凝血酶原时间与正常对照凝血酶原时间之比的ISI次方（ISI：国际敏感度指数，试剂出厂时由厂家标定），是可以校正凝血活酶 …

2017年12月5日 · Via LIN-28, FMRP controls progenitor cell behavior by post-transcriptionally repressing the level of insulin receptor (InR). This study identifies the stem cell-based …

Significant levels of InR mRNA, normalized to input materials, are pulled down using both proteins, compared to controls. Student’s t-test **** p-value = <0.0001. Stem cells are …

Mechanistically, Escargot suppresses insulin receptor (InR) signaling in stem cells to prevent differentiation. InR signaling suppression by Escargot is required for the preservation of stem …