STING and IRF3 in stromal fibroblasts enable sensing of ... - Nature
2020年6月1日 · Here, we show that direct contact between cancer cells and CAFs triggers the expression of a wide range of inflammatory modulators by fibroblasts. This is initiated following …
GPR162 activates STING dependent DNA damage pathway as a …
2023年2月1日 · In this study, we confirmed that GPR162, an orphan receptor in the G-protein-coupled receptor family, acted as a novel radiotherapy sensitizer by interacting with the …
A novel transcript isoform of STING that sequesters cGAMP and ...
We have used several different methods including luciferase assays, RT-qPCR, ELISA, electrophoretic detection of STING-α aggregates and biological assays for antiviral activity to …
武汉大学中南医院研究团队！全球都在追的“cGAS-STING”明信通 …
2024年1月13日 · cgas-sting信号通路是一种细胞内dna感应途径，在抗癌免疫应答期间激活i型干扰素（ ifn ）、促炎细胞因子和趋化因子的表达。因此，本研究探究了gpx4在coad中调节sting介 …
cGAS-like receptors drive a systemic STING-dependent host …
2024年12月24日 · cGAS-like receptor (cGLR)-stimulator of interferon genes (STING) recently emerged as an important pathway controlling viral infections in invertebrates. However, its …
Distinct pathogenic mutations in ARF1 allow dissection of its dual …
4 天之前 · Quantification of the mRNA levels of the ISGs Mx1, OAS1 and RSAD2 using qPCR indicated that STING was required for cGAMP signalling, both in ARF1 WT and R19C …
Redox homeostasis maintained by GPX4 facilitates STING …
2020年6月15日 · Here, we show that cellular redox homeostasis maintained by glutathione peroxidase 4 (GPX4) is required for STING activation. GPX4 deficiency enhanced cellular lipid …
STING高表达通过调控TLR4/NF-κB/NLRP3通路和影响炎症与凋亡 …
2024年7月14日 · SN-011对STING表达水平抑制效率验证. RT-qPCR检测显示，IRI组与Sham组相比，肾组织中STING的mRNA水平升高（P<0.05）；与IRI+DMSO组的差异无统计学意 …
Signaling Mechanism of Cuproptosis Activating cGAS-STING …
2024年9月20日 · With Cu-DPPZ-Py + and Cu-Elesclomol, there is strong evidence that the triggering cuproptosis significantly drives mitochondrial DNA (mtDNA) release to activate …
Protocol to induce and assess cGAS-STING pathway
2022年6月17日 · The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a pivotal role in several cellular processes including pathogen recognition and …
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