2024年12月25日 · STMN2 (Stathmin 2) is a Protein Coding gene. Diseases associated with STMN2 include Trichorhinophalangeal Syndrome, Type Ii and Creutzfeldt-Jakob Disease. Among its related pathways are Signaling by Rho GTPases and RND3 GTPase cycle. Gene Ontology (GO) annotations related to this gene include calcium-dependent protein binding and …

TDP-43的剪接靶点stathmin-2（STMN2）有可能在ALS中发挥关键作用。 研究发现下调TDP-43水平会导致数百个基因的表达发生变化，其中微管稳定调节因子STMN2是下调最严重的基因之一。

Constitutive STMN2 loss results in early-onset sensory and motor neuropathy featuring impaired motor behavior and dramatic distal neuromuscular junction (NMJ) denervation of fast-fatigable motor units, which are selectively vulnerable in ALS, without axon or motoneuron degeneration.

2023年3月17日 · TDP-43 mislocalization results in cryptic splicing and polyadenylation of pre-messenger RNAs (pre-mRNAs) encoding stathmin-2 (also known as SCG10), a protein that is required for axonal regeneration. We found that TDP-43 binding to a GU-rich region sterically blocked recognition of the cryptic 3' splice site in STMN2 pre-mRNA. Targeting dCasRx ...

2023年3月17日 · We found that TDP-43 binding to a GU-rich region sterically blocked recognition of the cryptic 3′ splice site in STMN2 pre-mRNA. Targeting dCasRx or antisense oligonucleotides (ASOs) suppressed cryptic splicing, which restored axonal regeneration and stathmin-2–dependent lysosome trafficking in TDP-43–deficient human motor neurons.

20257 Ensembl ENSG00000104435 ENSMUSG00000027500 UniProt Q93045 P55821 RefSeq (mRNA) NM_001199214 NM_007029 NM_025285 RefSeq (protein) NP_001186143 NP_008960 NP_079561 Location (UCSC) Chr 8: 79.61 – 79.67 Mb Chr 3: 8.57 – 8.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Stathmin-2 is a protein that in humans is encoded by the STMN2 gene. Function Superior cervical ganglion ...

2022年3月15日 · Both mosaic founders and homozygous loss-of-function Stmn2 mice exhibited neuromuscular junction denervation and fragmentation, resulting in muscle atrophy and impaired motor behavior, accompanied by an imbalance in neuronal microtubule dynamics in …

2019年1月14日 · STMN2 loss upon reduced TDP-43 function was due to altered splicing, which is functionally important, as we show STMN2 is necessary for normal axonal outgrowth and regeneration. Notably,...

2025年2月9日 · STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFbeta signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in hepatocellular carcinoma.

2025年2月9日 · STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFbeta signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in hepatocellular carcinoma. Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia. STMN2 is a key regulator functionally connected …