
Apoptotic stress causes mtDNA release during senescence and
2023年10月11日 · Using the antibody BAX6A7, which detects an active form of BAX 15, we found using 3D-SIM microscopy that, in senescent cells, peripheral globular mitochondria …
The conformational stability of pro-apoptotic BAX is dictated …
2021年8月13日 · BAX is a pro-apoptotic member of the BCL-2 family, which regulates the balance between cellular life and death. During homeostasis, BAX predominantly resides in the cytosol …
Bax Inhibitor-1: between stress and survival - PMC - PubMed …
ER stress-induced apoptosis was shown to require the pro-apoptotic members BAX and BAK of the BCL2 family to initiate mitochondrial dysfunction and cell death. Afterwards, a study …
Apoptotic stress induces Bax-dependent, caspase-independent
2020年9月18日 · We show here that the apoptotic stimuli cisplatin and staurosporine induce a Bax/Bak-dependent degradation and subcellular redistribution of nesprin-1 and nesprin-2 but …
BAX Redistribution Induces Apoptosis Resistance and Selective Stress …
Cancer therapies induce differential cell responses, ranging from efficient cell death to complete stress resistance. The BCL-2 proteins BAX and BAK govern the cellular decision between …
ROS mediated ER stress induces Bax-Bak dependent and
Conclusively, TDZ induced Bax-Bak dependent and independent apoptosis by enhancing ROS production followed by ER stress. Keywords: Apoptosis; Autophagy; Bcl-2; ER stress; …
ROS mediated ER stress induces Bax-Bak dependent and …
2018年10月1日 · Thioridazine (TDZ) induces ROS generation leading to ER stress mediated apoptosis. ROS inhibitor NAC and overexpression of Bcl-2 inhibit TDZ induced apoptosis. …
TRAF3IP3 Induces ER Stress‐Mediated Apoptosis with Protective …
4 天之前 · Different Flag-TRAF3IP3 plasmids or empty plasmids were transfected into A549 cells, and the results revealed that wild-type and transmembrane domain of TRAF3IP3 …
【细胞凋亡原创系列二】细胞凋亡通路 - 知乎 - 知乎专栏
当ER stress发生时,Bip/GRp78与内质网跨膜蛋白PERK、ATF6等的解离均能激活CHOP[1]。 CHOP诱导凋亡蛋白(如:GADD34、ERO1、DR5)的表达,可直接激活GADD34,促进ER …
Exercise reverses chronic stress-induced Bax oligomer formation …
We reveal that chronic, but not acute, stress increases cortical levels of Bax oligomer 270, a complex revealed in previous studies to be associated with apoptosis. Several recent studies …
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