2019年7月12日 · Cyclic sulfonamides (sultams) play a unique role in drug discovery and synthetic chemistry. A direct synthesis of sultams by an intramolecular C (sp 3)–H amidation reaction using an iron complex in situ derived from Fe (ClO 4) 2 and aminopyridine ligand is reported.

2018年1月23日 · Nowadays sultams are tremendously widely applied both in the medicinal field and in the synthetic field for the synthesis of different natural and non-natural heterocycles. This review covers the recent development (2011–June 2017) of powerful methodologies for the synthesis of sultams and their applications in various fields during this period.

磺酰胺，又称二 氨基 硫酰、硫酰胺，是一种 无机物，化学式SO2(NH2)2，具有易溶于醇，溶于热水，不溶于冷水，醚和苯的性质。 分子量96.11。 正交系片状 晶体，在常温下能吸收干的 氨气 生成无色的氨 络合物，在酸性、中性、碱性水溶液中性质稳定。 在空气中很稳定。 在250℃时分解，与无水H2SO4混合形成透明溶液，但经过15～30分钟后在常温下出现胺基硫酸白色沉淀。 与LiOH、 NaOH 或Ba (OH)2等 摩尔 的水溶液浓缩时生成 晶体 SO2N2H3Li、SO2N2H3Na或 …

2018年2月28日 · Nowadays sultams are tremendously widely applied both in the medicinal field and in the synthetic field for the synthesis of different natural and non‐natural heterocycles. This review covers the recent development (2011–June 2017) of powerful methodologies for the synthesis of sultams and their applications in various fields during this ...

Sultams are the sulfur analogs of lactams (cyclic amides) which demonstrate a broad range of medicinal activities and several lactam drugs are commercially available. In contrast, only a few sultam drugs are commercially available, while the presence of two oxygens on sulfur in sultam motifs can serve as a better H-bond acceptor than lactam ...

2011年4月5日 · γ-Sultams 7 are useful heterocycles for asymmetric synthesis and medicinal chemistry. Various protocols for the synthesis of the substituted sultams have been developed using as a key ring-formation step either C–N bond formation or C–C bond formation; however, some of these methods have been limited to a specific class of substrates.

2013年4月27日 · We have included in this review the principal methods for preparing mono- and polycyclic sultams with the exclusion of saccharin and other cyclic N -acylsulfonamides, the chemistry of which is too extensive. The reaction of sulfonyl chlorides with amines is the most widespread method for the synthesis of acyclic sulfonamides.

2015年4月3日 · A series of seven- and eight-membered ring –N,O–, –N,N–, and –N,S–sultams were effectively synthesized via tandem reactions involving oxa-, aza-, and thia-Michael addition to vinyl sulfonamides.

A catalyst-free, redox-neutral, and completely atom-economical reaction enables the synthesis of sultams by simply heating 2-nitrochalcones with elemental sulfur in 3-picoline or N-methylmorpholine (NMM).

2013年4月1日 · In this article, we aim to provide an overview of various developments made in the synthetic approaches to biaryl sultams via C H functionalization, with a futuristic emphasis on their ...