Real-time PCR quantification of spliced X-box binding protein 1
2019年7月22日 · For a more quantitative determination of XBP1 splicing activity, we measured the expression levels of total XBP1 (tXBP1: common region of s/uXBP1) and sXBP1 via real-time PCR using specific primer sets.
杨乃彬医生团队解读：XBP1在调控NASH进展中的作用|肝细胞|小 …
内质网应激下，核糖核酸内切酶ire1a诱导xbp1 mrna剪接，产生成熟mrna，编码活性转录因子剪接的xbp1 (sxbp1)。 此外，XBP1对胚胎肝脏的发育至关重要。 在不同的病例中，XBP1特异性缺失导致不同结果。
The unfolded protein response regulates hepatic autophagy by sXBP1 …
Obesity suppresses the expression of hepatic spliced XBP1 (X-box binding protein 1; sXBP1), the key transcription factor that promotes the adaptive UPR. Our RNA-seq analysis revealed that sXBP1 regulates genes involved in lysosomal function in the liver under fasting conditions.
XBP1 Gene - GeneCards | XBP1 Protein | XBP1 Antibody
2024年12月25日 · XBP1 (X-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with XBP1 include Major Affective Disorder 7 and Hematologic Cancer. Among its related pathways are Unfolded Protein Response (UPR) and Cellular responses to stimuli.
High expression of spliced X-Box Binding Protein 1 in lung
2020年6月23日 · We demonstrate for the first time that XBP1 splicing is a valuable marker of lung cancer aggressiveness, and our results support a model in which IRE1 downstream signaling could act as a regulator...
Real-time PCR quantification of spliced X-box binding protein ... - PubMed
2019年7月22日 · For a more quantitative determination of XBP1 splicing activity, we measured the expression levels of total XBP1 (tXBP1: common region of s/uXBP1) and sXBP1 via real-time PCR using specific primer sets.
Innate IRE1α-XBP1 activation by viral single-stranded RNA and its ...
2023年12月25日 · sXBP1 was detected in 17.91% of SARS-CoV-2 negative and 40.32% of SARS-CoV-2 positive patients (Fig. 1B). Quantitation of sXBP1 showed higher values in COVID-19 positive patients as compared to...
Cell子刊：王立堃团队发现抑制XBP1/胆固醇信号，可提高癌症免疫 …
2022年11月11日 · 该研究发现，肿瘤细胞内IRE1α/XBP1信号通路的活化通过促进自身胆固醇的合成和分泌，抑制抗肿瘤免疫，促进了肿瘤生长。 研究人员首先通过比较TCGA和GTEx数据库中肿瘤组织和正常组织中XBP1 mRNA表达水平，发现肿瘤组织中XBP1高表达。 进而选取黑色素瘤和结肠癌细胞并接种到小鼠身上，观察到肿瘤组织IRE1α/XBP1通路的激活。 接下来，研究者构建了IRE1α或者XBP1缺失的肿瘤细胞，发现该UPR通路的缺失能有效抑制肿瘤在野生型小鼠上的 …
IRE1α-XBP1 is a novel branch in the transcriptional regulation of
2015年11月16日 · Spliced Xbp1 (s Xbp1)-encoded proteins can translocate into the nucleus and induce the expression of ER-resident chaperones and ERAD components 21, 22. It was suggested that this IRE1α-XBP1...
The unfolded protein response regulates hepatic autophagy by sXBP1 …
Obesity suppresses the expression of hepatic spliced XBP1 (X-box binding protein 1; sXBP1), the key transcription factor that promotes the adaptive UPR. Our RNA-seq analysis revealed that sXBP1 regulates genes involved in lysosomal function in the liver under fasting conditions.
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