2004年7月15日 · Spleen tyrosine kinase (Syk), a nonreceptor protein kinase initially found to be expressed only in hemopoietic cells, has now been shown to be expressed in nonhemopoietic cells and to mediate signaling of various cytokines. Whether Syk plays any role in TNF signaling was investigated.

2010年5月14日 · Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that has long been thought to exclusively mediate signalling by receptors of the adaptive immune...

丝裂原活化蛋白激酶 (mitogen-activated protein kinase，MAPK)级联系统是真核生物细胞中高度保守的信号系统之一，参与诸多生物学过程的调控。 在细胞因子、神经递质及激素等不同信号的刺激下，MAPK级联逐步激活下游靶因子，控制着多种细胞过程，包括生长、免疫、炎症和应激反应等。 在不同细胞中，MAPK级联对细胞的作用随刺激物与刺激持续时间的不同而有所差异。 MAPK级联诱导Th分化，参与T细胞受体信号通路和B细胞受体信号通路。 MAPK级联调节癌症发生和 …

2013年3月28日 · Evaluation of the collateral mitogen-activated protein kinase (MAPK) pathway revealed a heterogeneous response to SYK inhibition in AML with downregulation of MEK and extracellular...

2020年11月6日 · Spleen tyrosine kinase (SYK) is an important oncogene and signaling mediator activated by cell surface receptors crucial for acute myeloid leukemia (AML)...

2004年7月15日 · We investigated whether TNF can activate Syk in hemopoietic and nonhemopoietic cells and whether Syk activation is involved in TNF-induced NF-κB, JNK, p38 MAPK, p44/p42 MAPK, and apoptosis. Our results indicate that TNF rapidly and potently activates Syk and that the deletion of Syk down-regulates TNF-induced activation of JNK, p38 MAPK, p44 ...

Evaluation of the collateral mitogen-activated protein kinase (MAPK) pathway revealed a heterogeneous response to SYK inhibition in AML with downregulation of MEK and extracellular signal-regulated kinase (ERK) phosphorylation in some AML cell lines but a paradoxical increase in MEK/ERK phosphorylation in RAS-mutated AML.

The integration of functional genomic screening with the study of mechanisms of intrinsic and acquired resistance in model systems and human patients identified resistance to SYK inhibitors through MAPK signaling in AML. The dual targeting of SYK and the MAPK pathway offers a combinatorial strategy to overcome this resistance.

The study revealed that the engagement of BTN2A1 with our coated anti-BTN2A1 mAb triggered SYK and MAPK signaling in M-CSF-induced immunosuppressive macrophages, leading to significant modifications of the phenotype, gene expression, and function.

Zymosan binds and activates TLR2 and Dectin-1 receptors simultaneously to induce Notch target gene expression through Syk and TLR2-mediated MAPK activation which activates expression of transcription factor cFos to promote gene expression, such as Hes1. MAPK: mitogen-activated protein kinases; TLR: toll-like receptors.