2016年3月1日 · t(15;17)(q24;21) is associated conbsistently with AML M3. This chromosomal abnormality first appeared to be confined to the characteristic or morphologically typical M3 …

The disease is characterized by a t(15;17) chromosomal translocation [4] involving the retinoic acid receptor alpha (RARA) gene and is distinguished from other forms of AML by its …

急性早幼粒细胞白血病（APL）类型特殊，存在特殊的细胞遗传学标志，最典型的改变为第15号和第17号染色体长臂发生平衡易位，形成特异染色体改变和融合基因产物PML-RARα。 随着靶 …

2008年11月16日 · Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) characterized by t(15;17)(q22;q21), a balanced reciprocal translocation …

急性早幼粒细胞白血病 是一类血癌，是由15号与17号染色体的遗传物质发生重组或易位而诱发的。 此类染色体的易位现象，在医学上被记为t（15；17），是15号染色体的 PML基因 的一部 …

The diagnostic translocation t (15;17) between chromosomes 15 and 17, which is responsible for the distinctive biology of APML, was definitively established in a seminal publication by …

Acute promyelocytic leukemia is characterized by a specific t (15;17) chromosomal translocation and a particular sensitivity to retinoic acid. The translocation fuses the PML gene to the …

1992年10月1日 · This chapter will focus on the characterization of the molecular events resulting from the t(15;17) translocation, namely the fusion of the retinoic acid receptor a gene (RARA) …

2023年12月9日 · 急性早幼粒细胞白血病（APL）是一种特殊类型的急性髓系白血病，其病理生理学涉及多个复杂的机制。 其中，t (15;17)易位是导致APL发病的重要因素之一，而凝血功能障 …

1991年8月23日 · A unique mRNA produced in leukemic cells from a t(15; 17) acute promyelocytic leukemia (APL) patient encodes a fusion protein between the retinoic acid receptor α (RARα) …