2015年12月1日 · IpaB is involved in a type III secretion system (T3SS) structure. It also controls the secretion of virulence factors and Shigella adhesion to host cells. In addition, it forms the ion pore, destroys phagosomes, and induces the immune cell's apoptosis or necrosis.

2024年9月1日 · IpaD π-helix deletion mutants retain their function in controlling T3SS protein secretion. Representative Western blots and resulting densitometry comparisons probing the impact of the engineered IpaD ΔQ148 and IpaD ΔY149 mutations on (A) uninduced and (B) Congo red induced secretion of T3SS proteins.

One of the most researched T3SS effector is IpaB from Shigella flexneri. It serves a double role, both as a translocator, creating a pore in the host cell membrane, and as an effector, exerting multiple detrimental effects on the host cell.

2010年12月1日 · Type III secretion systems (T3SSs) are key determinants of virulence in many Gram-negative bacterial pathogens. Upon cell contact, they inject effector proteins directly into eukaryotic cells through a needle protruding from the bacterial surface. Host cell sensing occurs through a distal needle “tip complex,” but how this occurs is not understood.

2019年7月13日 · Many Gram-negative bacteria pathogenic to plants and animals deploy the type III secretion system (T3SS) to inject virulence factors into their hosts. All bacteria that rely on the T3SS to cause infectious diseases in humans have developed antibiotic resistance.

Four hydrophilic IpaD molecules and one hydrophobic IpaB molecule are localized at the tip of the T3SS needle in the “off” state. IpaB senses host cells upon contact of the T3SS needle tip,...

2015年11月15日 · The type III secretion system (T3SS) is an essential virulence factor for Shigella flexneri, providing a conduit through which host-altering effectors are injected directly into a host cell to promote uptake. The type III secretion apparatus (T3SA) is composed of a basal body, external needle, and regulatory tip complex.

在这篇综述文章中，我们介绍了IpaB在感染志贺氏菌的宿主细胞中的作用的最新研究。 IpaB参与III型分泌系统（T3SS）结构。 它还控制毒力因子和志贺氏菌的分泌对宿主细胞的粘附。

2016年2月9日 · The T3SS apparatus (T3SA) is comprised of an envelope-spanning basal body and an external needle topped by a tip complex protein called IpaD. This nanomachine is used to deliver effector proteins into host cells to promote pathogen entry. A key component of the matured T3SS needle tip complex is the translocator protein IpaB.

Four hydrophilic IpaD molecules and one hydrophobic IpaB molecule are localized at the tip of the T3SS needle in the " off " state. IpaB senses host cells upon contact of the T3SS needle...