2024年12月25日 · TAF1 (TATA-Box Binding Protein Associated Factor 1) is a Protein Coding gene. Diseases associated with TAF1 include Dystonia 3, Torsion, X-Linked and Intellectual Developmental Disorder, X-Linked, Syndromic 33. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and …

2013年2月28日 · H3K4me3 is a prominent histone mark that is associated with active genes and promotes transcription through interactions with effector proteins that include initiation factor TFIID. We demonstrate that H3K4me3-TAF3 interactions direct global TFIID recruitment to active genes, some of which are p53 targets.

2023年3月17日 · 组蛋白H3第4位赖氨酸的甲基化修饰（H3K4）在进化上高度保守，是被研究最多的组蛋白修饰。 在酵母中，SET1蛋白是发现最早且唯一的H3K4甲基转移酶，含有SET1的复合物被命名为COMPASS（COMplexofProteinsAssociatedwithSet1）。

Because TAF1 protein may itself exhibit histone acetyltransferase activity, we also examined whether decreased TAF1 expression in XDP cell lines and post-mortem brain affects global levels of acetylated histone H3 (AcH3). The results demonstrate that total AcH3 are not altered in XDP post-mortem prefrontal cortex or cell lines.

2020年12月14日 · X-linked Dystonia-Parkinsonism (XDP) is a neurodegenerative disease linked to an insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of TAF1. This SVA insertion induces aberrant TAF1 splicing and partial intron retention, thereby decreasing levels of the full-length transcript.

SVA insertion in X-linked Dystonia Parkinsonism alters histone H3 acetylation associated with TAF1 gene. Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism. SET/TAF1 forms a distance-dependent feedback loop with Aurora B and Bub1 as a tension sensor at centromeres.

TATA 结合蛋白相关因子 1 和 7（TAF1 和 TAF7）是 TFIID 的两个亚基，是真核转录起始调节不可或缺的一部分，并在起始前复合物 (PIC) 组装中发挥关键作用。

Here, we examine a number of basic tenets of the hypothesis that TAF1 and Gcn5 are functionally redundant in vivo by examining whether each is necessary and sufficient to acetylate H3 in vivo. We further test whether TAF1 is functionally redundant with other HATs in vivo, genome wide.

2007年10月5日 · The TAF1 subunit of metazoan TFIID contains an acetyl-lysine binding activity residing in its double bromodomain (Jacobson et al., 2000). We compared the combined effects of acetylation and methylation of the histone H3 tail on TFIID and BPTF binding using the SILAC triple pull-down approach.

Our studies provide the first pieces of experimental data suggesting that histones are acetylated by a TAF1-dependent mechanism in vivo and that the acetylation of histone H3 within the proximal promoter region is required for Sp1 activation of cyclin D1 transcription.