2015年1月30日 · Numerous studies show that anti-TB drugs can be incorporated into liposomes, microparticles or nanoparticles which can be delivered as dry powders to the deep lungs for instantaneous, targeted and/or controlled release.

2022年7月1日 · The aerodynamic properties like mass median aerodynamic diameter (MMAD), emitted dose (ED), fine particle dose (FPD), and fine particle fraction (FPF) of the produced DPIs affect its therapeutic efficiency. Particles with <5 μm aerodynamic diameter are mainly deposited in the deep lung, whereas smaller particles of around 1 μm are exhaled out.

Total value of FPF currently stands at USD 6,560,000 million, in which USD 4,700,000 million is funded by USAID and USD 1,860,000 million is from STBP’s own funding. • USAID funding will be used for USAID priority countries (Tier 1 and Tier 2)

2019年7月7日 · The current standard first-line multi-drug treatment regimen for TB involves rifampicin (RIF), ethambutol (EMB), isoniazid (INH), and pyrazinamide (PZA). But the incidence of MDR-TB and XDR-TB strains is increasing which is alarming as they do not respond to the existing orally administered first-line therapeutics .

use part of its funds to set up a Flexible Procurement Fund (FPF) to function as a treasury facility. In addition, Stop TB Partnership (STBP) has decided to allocate funds from its savings over the past period to the FPF. This would offer guarantees to Procurement Agents

2024年5月1日 · Here, we present a novel and versatile strategy using micron-sized spherical particles with an excellent aerodynamic profile that dissolve in the lung fluid to ultimately generate nanoparticles enabling to enhance both extra- and intra-cellular drug delivery (i.e., dual micro-nano inhalation strategy).

2022年8月17日 · The main purpose of this study was to evaluate statistically the FPF generated using the latest NGI operated at various flow rates and the T2 fraction generated by using the oldest GTI operated at a fixed flow rate of 60 L/min. The study was performed on the FF and TB combination dry powder inhaler (DPI) product.

有效部位沉积量是气雾剂质量检查中的一个指标，通常粒径为1.0-5.0μm的药物，被认为可优先到达肺部，也称为微小粒子部分（FPF）。 这些粒子在细支气管和肺泡内沉积的量称为有效部位沉积量。

Fine particle fraction (FPF) is defined in general terms as the fraction or percentage of the drug mass contained in an aerosol cloud that may be small enough to enter the lungs and exert a clinical effect. An aerodynamic diameter of 5 μm represents the approximate border between "fine" and "coarse" …

The purpose of this study was to develop an inhalable combination dry powder formulation of bedaquiline and pyrazinamide and study their physicochemical properties and safety since this combination acts synergistically against Mycobacterium tuberculosis while pyrazinamide alone is active against latent TB and bedaquiline alone is active against ...