Phosphorylation of OPTN by TBK1 enhances its binding to Ub ... - PubMed
2016年4月6日 · By using quantitative proteomics, we show that Tank-binding kinase 1 (TBK1) phosphorylates all four receptors on several autophagy-relevant sites, including the ubiquitin- …
The EMBO Journal|Optineurin为TBK1的激活提供自噬接触位点
本篇研究中， 研究者发现发现自噬衔接蛋白Optineurin (OPTN)为TBK1激活提供了一个独特的平台。 TBK1敲除抑制了OPTN而不是NDP52在自噬体形成位点的定位，而敲除OPTN抑制TBK1的 …
Phosphorylation of OPTN by TBK1 enhances its binding to Ub ... - PNAS
2016年3月30日 · Constitutive interaction of TBK1 with OPTN and the ability of OPTN to bind to ubiquitin chains are essential for TBK1 recruitment and activation on mitochondria. TBK1 …
Neuron综述｜肌萎缩侧索硬化症（ALS）的发病机制和基因治疗方 …
optn也受到tank结合激酶1（tbk1）的调节，tbk1磷酸化optn，不仅能增加optn对泛素化底物的亲和力，还增加了其与lc3的结合清除损伤的蛋白。 除了在自噬相关的途径发挥作用，OPTN …
Structural insights into the interaction and disease mechanism of ...
2016年9月13日 · Optineurin is an important autophagy receptor involved in several selective autophagy processes, during which its function is regulated by TBK1. Mutations of optineurin …
RAB7A phosphorylation by TBK1 promotes mitophagy via the …
The activation of TBK1 within OPTN/SQSTM1-positive puncta on damaged mitochondria raised the question of whether TBK1 has substrates other than cargo receptors within the vicinity of …
Control of mitophagy initiation and progression by the TBK1 …
2024年6月25日 · Here, we demonstrate how the TBK1 (TANK-binding kinase 1) adaptors NAP1 (NAK-associated protein 1) and SINTBAD (similar to NAP1 TBK1 adaptor) restrict the initiation …
Adaptor‐Mediated Trafficking of Tank Binding Kinase 1 During …
2025年3月6日 · It is known that the TBK1 adaptor OPTN and the associated autophagy proteins NDP52, p62, and TAX1BP1 are phosphorylated on various residues at the site of xenophagy, …
Phosphorylation of OPTN by TBK1 enhances its binding to Ub
By using quantitative proteomics, we show that Tank-binding kinase 1 (TBK1) phosphorylates all four receptors on several autophagy-relevant sites, including the ubiquitin- and LC3-binding …
TBK1使OPTN磷酸化可增强其与Ub链的结合，并促进受损线粒体 …
受损线粒体的选择性自噬需要自噬受体optineurin（OPTN），NDP52（CALCOCO2），TAX1BP1和p62（SQSTM1）将泛素化的货 …