Tbr1 is a protein, called a transcription factor, that binds to DNA and regulates the transcription of genes into mRNA. It is expressed in postmitotic projection neurons and is critical for normal brain development. Tbr1 has been shown to be expressed in the developing olfactory bulb. Tbr1 has also been observed in the developing cerebral ...

2024年12月25日 · TBR1 (T-Box Brain Transcription Factor 1) is a Protein Coding gene. Diseases associated with TBR1 include Intellectual Developmental Disorder With Autism And Speech Delay and Intellectual Developmental Disorder With Speech Delay, Autism, And Dysmorphic Facies. Among its related pathways is Neuroscience.

t 盒脑蛋白 1 (tbr1) 是脊椎动物胚胎发育过程中的一个重要转录因子。 作为 T 盒转录因子家族的一员， TBR1 在有丝分裂后期谷氨酸能投射神经元中表达。

2015年11月2日 · In this review, we summarize the physiological functions of TBR1 and the currently understood mechanisms by which TBR1 mutations cause ASDs. Based on the data accumulated from the mouse model, we suggest that abnormal brain wiring and reduced neuronal activity in the amygdala are the primary causes for TBR1 -dependent ASDs. Table 1.

2001年2月1日 · The high expression of Tbr1 in the preplate and cortical plate suggested that Tbr1 might play an important role in cortical development. To investigate this hypothesis, we examined the expression of Tbr1 protein in the developing cortex and studied mice with a loss-of-function mutation of the Tbr1 gene (Bulfone et al., 1998) .

2022年12月29日 · TBR1 is a neuron-specific transcription factor involved in brain development and implicated in a neurodevelopmental disorder (NDD) combining features of autism spectrum disorder (ASD), intellectual disability (ID) and speech delay.

Here, we demonstrate that T-box transcription factor T-brain 1 (Tbr1) is expressed in 2 groups of morphologically and functionally distinct RGCs: the orientation-selective J-RGCs and a group of OFF-sustained RGCs with symmetrical dendritic arbors. When Tbr1 is genetically ablated during retinal development, these 2 RGC groups cannot develop.

As a marker of newborn neuron, Tbr1 is involved in the cortical lamination and affects the processes of cell migration and neural differentiation. Key words: Cortical lamination, Differentiation,...

2023年12月13日 · 皮层谷氨酸能特异性模块包括Tbr1和Satb2，它们在不同亚类中也表现出差异表达。 直接早期基因Egr3和Nr4a1在大脑皮层谷氨酸能神经元中高表达，而Fos和Fosb表达更为均匀。

2015年11月3日 · T-brain-1 (TBR1) is a brain-specific T-box transcription factor. In 1995, Tbr1 was first identified from a subtractive hybridization that compared mouse embryonic and adult telencephalons. Previous studies of Tbr1 (-∕-) mice have indicated critical roles for TBR1 in the development of the cerebral c …