2023年6月29日 · This paper describes the scalable and detailed preparation of TBS-MAC 1 from acetylmalononitrile 7, such that this valuable masked acyl synthon can be accessed reliably in 60–70% yields at three synthetically useful scales of 0.75 g, 1.5 g, or 3.0 g. TBS-MAC 1 can be

2017年6月12日 · MAC-TBS Reagent Usable for Three Component Coupling Reactions ( tert -Butyldimethylsilyloxy)malononitrile ( 1 ), developed by Nemoto et al ., is called a MAC (Masked Acyl Cyanide) reagent. 1) 1 forms an anion species 2 by the treatment of a base and 2 acts as an acyl anion equivalent.

2023年6月29日 · This paper describes the three-step synthesis of TBS-MAC, a masked acyl cyanide (MAC) and a versatile one-carbon oxidation state three synthon. We have developed a scalable and detailed synthesis that involves: (1) acetylation of malononitrile to form the sodium enolate, (2) protonation of the enola …

2023年6月29日 · 本文描述了 TBS-MAC、掩蔽酰基氰化物 (MAC) 和多功能一碳氧化态三合成子的三步合成。 我们开发了一种可扩展且详细的合成方法，包括：（1）丙二腈乙酰化形成烯醇钠，（2）烯醇化物质子化形成乙酰丙二腈，（3）烯醇环氧化，重排成不稳定的醇，以及TBS-保护形成标题化合物。 烯醇钠和乙酰基丙二腈都是中间体羟基丙二腈的实验室稳定前体，可以通过改变保护基（Ac、MOM、EE 等）将其转化为 TBS 之外的其他 MAC 试剂。 本文描述了 TBS-MAC …

Abstract: This paper describes the three-step synthesis of TBS-MAC, a masked acyl cyanide (MAC) and a versatile one-carbon oxidation state three synthon. We have developed a scalable and detailed

2023年6月29日 · This paper describes the three-step synthesis of TBS-MAC, a masked acyl cyanide (MAC) and a versatile one-carbon oxidation state three synthon. We have developed a scalable and detailed

2023年6月18日 · 下行mac层吞吐率由pdcch dl grant（下行调度次数）乘以pdsch tbs（与mcs、rb、rank相关的传输块大小）再减去bler（误码率）的百分比。同样，上行mac层吞吐率的计算方式类似，只是将pdcch ul grant与pusch tbs相乘。

2023年6月29日 · tbs-mac作为一种多功能的一碳氧化态三元合成子，在有机合成领域具有广泛的应用前景。 通过该合成方法，研究人员能够高效地合成TBS-MAC，并进一步将其转化为其他具有不同保护基团的化合物，拓展了MAC试剂的应用范围。

This paper describes the three-step synthesis of TBS-MAC, a masked acyl cyanide (MAC) and a versatile one-carbon oxidation state three synthon.

This paper describes the three-step synthesis of TBS-MAC, a masked acyl cyanide (MAC) and a versatile one-carbon oxidation state three synthon.