2024年12月25日 · TBX21 (T-Box Transcription Factor 21) is a Protein Coding gene. Diseases associated with TBX21 include Asthma, Nasal Polyps, And Aspirin Intolerance and …

Our results show for the first time the likely impact of the TBX21 (T-bet) immune gene in LOAD development and that the elevated TBX21 mRNAs in the WBCs of LOAD patients may …

2025年2月8日 · This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression …

2013年10月11日 · T-bet (encoded by Tbx21) represses tumour necrosis factor (TNF) expression in colonic DCs. In the absence of T-bet, TNF from DCs causes colonic epithelial cell apoptosis …

Naive T helper (Th) cells differentiate into 2 subsets, Th1 and Th2, each with distinct functions and cytokine profiles. TBX21 is a Th1-specific T-box transcription factor that controls the …

The T-box transcription factor T-bet (Tbx21) has emerged as a key regulator of type 1-like immunity, playing critical roles in the establishment and/or maintenance of effector cell fates in …

2018年4月3日 · Results: In the training and test sets, TBX21 could classify 1389 LUAD patients into high and low-risk groups with significantly different prognosis (P < 0.01). Its prognostic …

TBX21, a gene that encodes for the transcription factor T-box expressed in T cells, is responsible for the induction of T H 1 cells and the suppression of T H 2 cells from naive T lymphocytes. …

Tbx21 directly activates interferon-gamma gene transcription and enhances development of Th1 cells. 18 TBX21 also plays multiple roles in many subtypes of immune cells. 19,20 Although …

2022年4月4日 · Here, we show that T helper-1 (Th1) cells and natural killer (NK) cells displayed distinct epigenomes at the Tbx21 locus, which encodes T-bet, a critical TF for regulating type …