Dec 25, 2024 · TBX21 (T-Box Transcription Factor 21) is a Protein Coding gene. Diseases associated with TBX21 include Asthma, Nasal Polyps, And Aspirin Intolerance and Immunodeficiency 88. Among its related pathways are IL27-mediated signaling events and IL12-mediated signaling events.

Our results show for the first time the likely impact of the TBX21 (T-bet) immune gene in LOAD development and that the elevated TBX21 mRNAs in the WBCs of LOAD patients may represent a new easy diagnostic test for Alzheimer’s disease.

Feb 8, 2025 · This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG).

Oct 11, 2013 · T-bet (encoded by Tbx21) represses tumour necrosis factor (TNF) expression in colonic DCs. In the absence of T-bet, TNF from DCs causes colonic epithelial cell apoptosis in the context of the ...

Naive T helper (Th) cells differentiate into 2 subsets, Th1 and Th2, each with distinct functions and cytokine profiles. TBX21 is a Th1-specific T-box transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG; 147570) (Szabo et al., 2000).

The T-box transcription factor T-bet (Tbx21) has emerged as a key regulator of type 1-like immunity, playing critical roles in the establishment and/or maintenance of effector cell fates in T and B lymphocytes, as well as dendritic cells and natural killer cells.

Apr 3, 2018 · Results: In the training and test sets, TBX21 could classify 1389 LUAD patients into high and low-risk groups with significantly different prognosis (P < 0.01). Its prognostic power was independent of other clinical factors including stage, age, gender and smoking status.

TBX21, a gene that encodes for the transcription factor T-box expressed in T cells, is responsible for the induction of T H 1 cells and the suppression of T H 2 cells from naive T lymphocytes. TBX21 knockout mice have asthma-like inflammation.

Tbx21 directly activates interferon-gamma gene transcription and enhances development of Th1 cells. 18 TBX21 also plays multiple roles in many subtypes of immune cells. 19,20 Although TBX21 expression is required for protection against pathogens, exuberant T-bet–regulated immune responses can be a driving force in inflammatory diseases. 21 ...

Apr 4, 2022 · Here, we show that T helper-1 (Th1) cells and natural killer (NK) cells displayed distinct epigenomes at the Tbx21 locus, which encodes T-bet, a critical TF for regulating type 1 immune responses.