2023年6月20日 · Click chemistry was used to prepare TC-Thio, a new artificial metallo-nuclease. TC-Thio coordinates up to three Cu II ions and is a potent DNA damaging agent that binds …

2023年6月20日 · Click chemistry was used to prepare TC-Thio, a new artificial metallo-nuclease. TC-Thio coordinates up to three CuII ions and is a potent DNA damaging agent that binds and …

2023年8月3日 · The oxidative DNA damaging properties of a polynuclear copper binding ligand called TC-Thio is demonstrated. Copper-TC-Thio binds in the minor groove of genomic DNA …

We selected biologically inert reaction partners tri-azidomethyl-mesitylene and ethynyl-thiophene to develop TC-Thio, a bioactive C3-symmetric ligand in which three thiophene-triazole …

点击化学用于制备 TC-Thio，一种新型人工金属核酸酶。TC-Thio 最多可协调三个 Cu II离子，是一种有效的 DNA 损伤剂，可结合小沟并从中裂解。使用 DNA 单分子成像评估原代人类细胞的 …

The calculated electronic structure of the trinuclear Cu II -TC-Thio complex showed each Cu atom coordinated to TC-Thio in a monodentate fashion through a triazole nitrogen donor (N3) and to ...

2023年8月10日 · The team identified how TC-Thio, in the presence of copper ions, could bind and cleave DNA, and found that its DNA damaging properties were similar to Temozolomide, a …

2023年8月9日 · The development of copper-TC-Thio demonstrates the potential of click chemistry in designing new metal-based drugs, paving the way for the development of clinically relevant …

2023年8月10日 · The compound, called Tri-Click Thiophene, or TC-Thio, is a promising class of anti-cancer agents that binds and cuts cancer DNA. Through their research, the team was...