2023年9月9日 · Fumarate hydratase (FH) is an enzyme of the Tricarboxylic Acid (TCA) cycle whose mutations lead to hereditary and sporadic forms of cancer.

延胡索酸水化酶 （FH）是参与三羧酸（TCA）循环的代谢酶，催化延胡索酸盐向苹果酸盐的可逆转化，已被证实是一种肿瘤抑制因子，FH的突变可导致 遗传性平滑肌瘤病肾癌 （HLRCC， …

2023年3月8日 · Fumarate hydratase (FH), a metabolic enzyme of the tricarboxylic acid (TCA) cycle that catalyses the reversible conversion of fumarate to malate, has been identified as a...

2023年5月25日 · 富马酸水合酶（fh）为三羧酸（tca）循环的一种代谢酶，已被确定为真正的肿瘤抑制因子。 FH的缺失会导致富马酸的积累，进而激活一系列致癌级联反应驱动恶性转化和肿 …

Fumarate hydratase (FH) is an enzyme of the Tricarboxylic Acid (TCA) cycle whose mutations lead to hereditary and sporadic forms of cancer. Although more than twenty years have …

2024年6月1日 · Fumarate hydratase (FH) and fumarate are now known to regulate cytokine production. Recent findings suggest FH loss leads to mitochondrial nucleic acid release, …

Fumarate hydratase (FH) is an evolutionary conserved TCA cycle enzyme that reversibly catalyzes the hydration of fumarate to L-malate and has a moonlight function in the DNA …

2020年8月3日 · Fumarate hydratase (FH) is an enzyme in the tricarboxylic acid (TCA) cycle, biallelic loss-of-function mutations of which are associated with hereditary leiomyomatosis...

同样，通过使用 fh-in-1（一种 fh 抑制剂 (fhi)）积累内在富马酸盐，以浓度和时间依赖性方式强烈抑制 cd8+ t 细胞活化。 进一步分析表明，这种内源性和外源性富马酸盐积累的作用只发生在 …

Several cancers harbor mutations that affect the integrity of this cycle, mostly at the levels of isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), and fumarate hydratase …