αβ型t细胞受体通过识别细胞表面mhc-肽复合物实现其功能，该复合物指的是结合于mhc分子结合沟内的肽段，强调了tcr对肽段和mhc分子的双重识别。 值得注意的是，特定T细胞受体仅能识别与MHC I或MHC II相连的肽段，而不能同时识别两者（人类的MHC称为 HLA ）。

t细胞通过tcr识别mhc/抗原肽后，出现一系列和激活有关的事件。 信号跨膜传递和转导通路的启动; 抗原激活信号胞内转导的主要途径 ; t细胞激活的第二信号 ; 信号跨膜传递和转导通路的启动. tcr和mhc/抗原肽的结合，引起细胞膜上相关分子的多聚作用（下图）。

2024年7月2日 · Here we present TCR mapping of antigenic peptides (TCR-MAP), an antigen discovery method that uses a synthetic TCR-stimulated circuit in immortalized T cells to activate sortase-mediated...

2021年12月13日 · Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside...

2024年12月13日 · Here, we introduce targeted recognition of antigen–MHC complex reporter for MHC I (TRACeR-I), a generalizable platform for targeting peptides on polymorphic HLA-A*, HLA-B* and HLA-C* allotypes...

In this review, we focus on the TCR recognition of peptide (p) presented by MHC class I (MHC-I) molecules only. The MHC-I antigen binding cleft is closed at the N-terminal and C-terminal regions (Figure 1 A), while MHC-II molecules have an open-ended cleft.

In the last four years, the atomic structures of more than a half-dozen of the intercellular recognition complexes, formed by αβT cell receptors (αβTCR) on cytotoxic T lymphocytes (CTL) or T helper cells and MHC/peptide complexes on antigen presenting cells, have been visualized by X-ray crystallography (Figure 1A).

T细胞抗原受体(T-cell receptor, TCR)是位于T细胞表面的一种异二聚体蛋白，是T细胞表面特异性识别抗原和介导免疫应答的分子。由于细胞内存在重排机制，导致TCR基因序列多样性，是基因组中多态性最高的区域之一，决定着人的免疫系统对适应环境的适应。

2020年12月23日 · The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR). This recognition event is the first step that leads to T cell activation, and in turn can dictate disease outcomes.

2024年7月16日 · TCR-MAP是一种利用合成TCR刺激回路激活免疫细胞胞外标签的方法。具体来说，通过在永生化Jurkat T细胞中使用合成回路，激活Sortase介导的工程抗原呈递细胞（APCs）的标签，从而使得带标签的活体APCs能够直接被纯化并通过测序进行解码。