2021年12月13日 · Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside...

2001年1月12日 · In the last four years, the atomic structures of more than a half-dozen of the intercellular recognition complexes, formed by αβT cell receptors (αβTCR) on cytotoxic T lymphocytes (CTL) or T helper cells and MHC/peptide complexes on antigen presenting cells, have been visualized by X-ray crystallography (Figure 1A).

2024年7月2日 · Here we present TCR mapping of antigenic peptides (TCR-MAP), an antigen discovery method that uses a synthetic TCR-stimulated circuit in immortalized T cells to activate sortase-mediated...

2022年8月23日 · Interactions between a T cell receptor (TCR) and a peptide-major histocompatibility complex (pMHC) ligand are typically mediated by noncovalent bonds. By studying T cells expressing natural or...

2023年1月20日 · The regulatory and effector functions of T cells are initiated by the binding of their cell-surface T cell receptor (TCR) to peptides presented by major histocompatibility complex (MHC) proteins on other cells. The specificity of TCR:peptide-MHC interactions, thus, underlies nearly all adaptive immune responses.

2014年4月10日 · We show that force prolongs lifetimes of single TCR-pMHC bonds for agonists (catch bonds) but shortens those for antagonists (slip bonds).

2016年12月8日 · The extent to which T cell receptors (TCRs) are biased towards MHC proteins in particular has been widely discussed. In a recent paper, Sharon et al. report direct evidence for coevolution between TCR and MHC genes, helping to explain how MHC compatibility and bias can be encoded within TCRs.

2021年6月4日 · Evidence suggests that the canonical TCR–pMHC docking polarity is driven by evolutionary hardwiring of complementary germline-encoded motifs at the TCR and MHC interface. An alternate model suggests that TCR recognition of pMHC is driven during thymic selection by the need for the CD4 or CD8 coreceptors to bind MHC and deliver coreceptor ...

2025年2月27日 · This process relies on a mechanically flexible TCR-pMHC binding interface, which enables force-enhanced CD8 coreceptor binding to MHC-α 1 α 2 domains through sequential conformational changes induced by force in both the MHC and CD8. Conversely, engineered high-affinity TCRs create rigid, tightly bound interfaces with cognate pMHCs of their ...

2023年4月26日 · Structural characterization is key for understanding the specificity of TCR-pMHC interactions and informing the development of therapeutics. Despite the rapid rise...