2024年1月22日 · In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-43 is depleted from the nucleus. TDP-43 loss leads to cryptic exon inclusion but a role in other RNA processing events remains unresolved. Here, we show that loss of TDP-43 causes widespread changes in alternat …

TDP的英文全称是“Thermal Design Power”，中文直译是“散热设计功耗”。主要是提供给计算机系统厂商，散热片/风扇厂商，以及机箱厂商等等进行系统设计时使用的。

2019年2月15日 · Here, we report that TDP-43 participates in the DNA damage response and its nuclear clearance in motor neurons causes DNA double-strand break repair defects in ALS. Our findings uncover a link between TDP-43 pathology and impaired DNA repair, and suggest potential avenues for DNA repair-targeted therapies for TDP-43–ALS.

2022年2月23日 · Our findings, which demonstrate a genetic link between loss of nuclear TDP-43 function and disease, reveal the mechanism by which UNC13A variants exacerbate the effects of decreased TDP-43...

2024年7月23日 · Stress-induced nuclear condensation transiently inactivates TDP-43, leading to loss of interaction with its protein binding partners and loss of function in splicing. Splicing changes are especially prominent and persisting for STMN2 RNA, and STMN2 protein becomes rapidly depleted early during stress.

3 天之前 · We found that TDP-43 CLIP targets were enriched in transcripts positively correlated with TDP-43 (Supplementary Fig. 11a; odds ratio 4.64, Fisher’s exact test, P < 0.0001). This is consistent ...

2024年1月23日 · TDP-43 loss leads to cryptic exon inclusion but a role in other RNA processing events remains unresolved. Here, we show that loss of TDP-43 causes widespread changes in alternative polyadenylation, impacting expression of disease-relevant genes (e.g., ELP1, NEFL, and TMEM106B) and providing evidence that alternative polyadenylation is a new ...

2024年11月1日 · Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by nuclear depletion and cytoplasmic aggregation of TAR DNA-binding protein-43 (TDP-43). TDP-43 plays a key role in regulating the splicing of numerous genes, including TARDBP. This review aims to delineate two aspects of ALS/FTD pathogenesis associated with ...

2024年1月26日 · TDP-43 loss of function causes widespread cryptic splicing that can reduce the expression of mRNA transcripts. Here, we demonstrate that such mis-splicing can also generate de novo proteins from pathological transcripts. Our studies indicate that the inclusion of CEs in proteins can, in certain instances, alter their interacting protein partners.

2021年10月25日 · Our results show that loss of TDP-43 function underlies hippocampal and cortical synaptic degeneration in TDP-43 proteinopathies. Nuclear protein TAR DNA/RNA binding protein 43 (TDP-43) has...