Myelodysplastic Syndrome associated TET2 mutations affect NK …
2023年2月3日 · Natural Killer (NK) cells play a role in the anti-leukemic immune response via their cytolytic activity. Here we show that patients with MDS clones harbouring mutations in the...
Frequent somatic TET2 mutations in chronic NK-LGL leukemia …
2021年8月26日 · Patients with STAT3 mutation, inclusive of those with TET2 comutation, had lower hematocrit, hemoglobin, and absolute neutrophil count compared with STAT3 wild-type …
Myelodysplastic Syndrome associated TET2 mutations affect NK …
2023年2月3日 · Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders, representing high risk of progression to acute myeloid leukaemia, and frequently associated to …
DNA demethylase Tet2 promotes the terminal maturation of
2024年6月13日 · Here we studied the modulatory role of Tet2 in NK cell development and maturation by generating hematopoietic Tet2 knockout mice and mice with Tet2 conditional …
TET2 regulates extranodal NK/T cell lymphoma progression …
The biological role of Ten-11 translocation 2 (TET2) and the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in the development of extra-nodal natural killer/T …
Frequent somatic TET2 mutations in chronic NK-LGL leukemia …
2021年8月26日 · We present the discovery of TET2 mutations in chronic NK-LGL leukemia and evidence that it identifies a unique molecular subtype. Chronic natural killer large granular …
Linking the KIR phenotype with STAT3 and TET2 mutations to …
2021年6月10日 · STAT3 and TET2 mutations were respectively identified in 27% and 34% of the patients with CLPD-NK, constituting a new diagnostic hallmark for this disease. TET2-mutated …
TET2 mutation in acute myeloid leukemia: biology, clinical …
2024年11月9日 · Experiments based on samples from myelodysplastic syndrome (MDS) patients found that TET2 mutations lead to phenotypic defects in circulating NK cells. TET2 mutations …
DNA demethylase Tet2 promotes the terminal maturation of
Here we studied the modulatory role of Tet2 in NK cell development and maturation by generating hematopoietic Tet2 knockout mice and mice with Tet2 conditional deletion in NKp46 + NK cells.
Myelodysplastic Syndrome associated TET2 mutations affect NK …
2023年2月3日 · Natural Killer (NK) cells play a role in the anti-leukemic immune response via their cytolytic activity. Here we show that patients with MDS clones harbouring mutations in the …