Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three [1] different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages.

TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand.

2024年3月22日 · Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every tissue and cell type. The signal transduction of TGF-β can stimulate diverse...

TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury repair through coordinated effects on cell proliferation, phenotypic plasticity, migration, metabolic adaptation, and immune surveillance of multiple cell types in shared ecosystems.

转化生长因子β (transforming growth factor-β，TGF-β)是血管再狭窄中重要的调控分子，在血管再狭窄的发生、发展中发挥关键作用。 TGF-β是TGF-β超家族成员之一，可与TGF-β受体相结合，通过经典的依赖Smad蛋白通路或非经典通路将膜外信号转导到膜内，从而调控细胞的生长、增殖、分化和凋亡的过程。 血管再狭窄至今仍是心脑及外周血管疾病中难以攻克的世界性难题之一，其发生、发展机制具有多样性和复杂性。 预防术后血管再狭窄或延长血管通畅时间具有重要的临 …

2016年4月25日 · Inhibition of the TGF-β isoform, TGF-β1, or its downstream signalling pathways substantially limits renal fibrosis in a wide range of disease models whereas overexpression of TGF-β1 induces...

2016年12月20日 · 转化生长因子-β (transforming growth factor-β, TGF-β)在细胞的自我调控包括细胞增殖、分化、凋亡、胚胎发育、免疫监督、血管再生等过程中发挥重要作用。 TGF-βⅢ型受体 (TβRⅢ)是TGF-β超家族的辅助受体之一，TβRⅢ不仅能介导TGF-β超家族配体依赖的Smad经典通路，还可以介导非Smad依赖的信号通路，参与调控细胞的多种信号通路，在纤维化、肿瘤、心血管系统等疾病中发挥重要作用。 该文就TβRⅢ参与的信号通路及其在纤维化疾病中的作用作一 …

结论OM作用于HS成纤维细胞可产生抑制效应，其部分机制是通过TGF—β—Smad信号通路的负性调节，实现对细胞的胶原合成及收缩功能的抑制。 Skip to search form Skip to main content Skip to account menu

2010年12月22日 · The long form of Latent TGF-β binding protein 1 (LTBP1L) covalently binds all TGF-β isoforms and regulates their bioavailability. Ltbp1L expression analysis during valvulogenesis revealed two patterns of Ltbp1L production: an early one (E9.5–11.5) associated with endothelial-to-mesenchymal transformation (EMT); and a late one (E12.5 to ...

TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form dimers via disulfide links (except for GDF-3, -9, BMP-15, and Lefty), which serve as the active ligand. Although homodimers are considered the standard form, there are natural heterodimers with biological activity.