2012年9月4日 · TGFβ enhances IL4-induced microglia alternative activation by strongly increasing the expression of Arg1 and Ym1. This synergistic effect on Arg1 induction is almost completely blocked by the application of the MAPK inhibitor, PD98059.

2021年3月12日 · In addition, TGF-β alone could increase the mRNA levels Arg1 in PEMs (fig. S5C). In addition, we suggest that the in vivo M6T treatment could also push microglia polarization toward tissue repair microglia in TBI mice via increasing gene expression for the clearance of apoptotic cells, promoting new blood vessel formation, and response to IL-6 ...

本研究在诱导体系中加入转化生长因子β（tgf-β），采用流式细胞仪分析诱导的mdscs的表型。 通过将 MDSC 与受刺激的 T 细胞共培养确定其潜在的免疫抑制功能和机制体外并将 MDSC 转移到皮肤移植的 C57BL/6J 小鼠模型中体内.

2025年2月14日 · We found that deleting Arg1 in LysM-positive macrophages reduced TGF-beta signaling, a crucial pathway regulating fibrosis, in microglial cells in the peri-infarct cortex. This decrease in TGF-β activity in microglia near the infarction border may contribute to the reduced fibrotic scarring observed in Arg1 cKO mice.

2024年6月21日 · Here we show that MG-Tgfb1 iKO mice present cognitive deficits, supporting that precise spatial regulation of TGF-β1 ligand derived from microglia is required for the maintenance of brain ...

2023年8月8日 · We observed that TGF-β increased the expression of the anti-inflammatory genes Arg1 and Retnla but suppressed the expression of the proinflammatory genes Tnfa, Il6, and Nos2 in response to LPS as well as to other TLR ligands (Fig. 2, K and L). TGF-β decreased the production of TNF-α and IL-6 in a dose-dependent manner (fig. S2F).

2019年8月1日 · Macrophage depletion in the elastase + anti-TGF-β group led to a significant decrease of IL-1β, IL-6, ARG1, and Ym1/2 gene expression. Immunofluorescent staining confirmed that TGF-β neutralization significantly enhanced ARG1 protein expression in the aneurysmal tissue.

TGF-β neutralization finely tunes macrophage phenotype in elastase-induced AAA and leads to an increase in ARG1 gene and protein expression in the aortic wall. Even if further studies are required to elucidate its role in AAA development, ARG1 could represent a new prognostic or therapeutic target i …

Numidargistat (CB-1158) 二盐酸盐 (CB-1158) 是一种 ARG1 抑制剂，通过减少晶状体上皮细胞 (LEC) 的增殖和减少纤连蛋白、α-SMA、胶原蛋白 1A1 来抑制 TGF-β2 诱导的前囊下白内障 (ASC)和波形蛋白表达。

2016年5月3日 · Here, we found that TNF antagonized alternative activation of macrophages and dendritic cells by IL-4. TNF inhibited IL-4-induced arginase 1 (Arg1) expression by decreasing histone acetylation, without affecting STAT6 phosphorylation and nuclear translocation.