In human, transforming growth factor β1 (TGF-β1) is considered central in the pathogenesis. Objectives: To investigate TGF-β1 pathway in IPF. Animals: Lung tissues from 12 affected and 11 control dogs. Serum from 16 affected West Highland white Terriers (WHWTs) and healthy dogs from predisposed (13 WHWTs, 12 Scottish Terriers and 13 Bichons ...

2021年6月14日 · In this study, we examined the potential of TGF-β1 as a therapeutic target in canine melanoma by confirming TGF-β1 production in melanoma cell lines and evaluating TGF-β1 serum concentrations in dogs with oral malignant melanoma (OMM).

2014年10月20日 · Transforming growth factor β1 serum concentration was evaluated with the hypothesis that a high circulating concentration would be a marker of high TGF‐β1 lung activity in dogs with IPF and that it could be used as a biomarker. Surprisingly, no difference was seen between affected and healthy WHWTs, which precludes its use as a biomarker.

Because fibrosis is a part of the alteration in the effected joints, we investigated the transforming growth factor beta 1 (TGF-β1) as an important regulation molecule of tissue fibrosis. We chose Osteoarthritis following a cruciate ligament rupture (CLR) because it is …

2024年8月12日 · In this study, we aimed to determine whether pirfenidone, a drug that has shown antifibrotic effects in various clinical studies, also exerts antifibrotic effects on canine renal tubular epithelial cells, Madin-Darby canine kidney cells (MDCK).

Osteoarthritis is a common problem in daily veterinary practice with insufficient knowledge about disease mechanism. Because fibrosis is a part of the alteration in the effected joints, we investigated the transforming growth factor beta 1 (TGF-β1) as an important regulation molecule of tissue fibrosis.

The present study investigates immunohistochemically the expression of TGF-beta1, -beta2, -beta3 and smooth muscle alpha actin (alpha-SMA) in normal canine mitral valves (MVs) (n=10) and in the valves of dogs with mild (n=7), moderate (n=14) and severe (n=9) CVD.

In human medicine, there is growing evi-dence that Tregs and their cytokines Interleukin 10 (IL-10) and transforming growth factor-beta 1 (TGF-ß1) play an important role in the ASIT mode of action.8–15 In veterinary medicine, very few studies focused on Tregs, IL-10 and TGF-ß1 in CAD and their role dur-ing ASIT.

2013年12月5日 · The aim of this study was to evaluate TGF-b1 bio-chemical pathways in healthy dogs and dogs with IPF. Specifically, the concentration of circulating TGF-b1 was evaluated in addition to lung expression and localization of this molecule as well as proteins involved in its storage (LTBPs) and activation (amb6 and amb8 integrins and THBS1). We ...

2014年10月20日 · Transforming growth factor β1 serum concentration was evaluated with the hypothesis that a high circulating concentration would be a marker of high TGF-β1 lung activity in dogs with IPF and that it could be used as a biomarker. Surprisingly, no difference was seen between affected and healthy WHWTs, which precludes its use as a biomarker.