Feb 3, 2025 · Transforming growth factor-β (TGF-β) is a potent pro-fibrotic cytokine that signals through canonical and non-canonical pathways to promote kidney cell damage and fibrosis …

Transforming growth factor-beta (TGF-beta) regulates cell proliferation, differentiation and apoptosis, and TGF-beta-related proteins have key roles in development, tissue homeostasis …

Transforming growth factor-β (TGF-β) is a potent pro-fibrotic cytokine that signals through canonical and non-canonical pathways to promote kidney cell damage and fibrosis …

In this review, we describe evidence that supports current insights into the mechanism and function of TGF-β-activated kinase 1 (TAK1), which has emerged as a critical signaling …

Aug 25, 2018 · Transforming growth factor-β1 (TGF-β1) is considered as a crucial mediator in tissue fibrosis and causes tissue scarring largely by activating its downstream small mother …

Rohan Manohar (Scholar Rock, Cambridge, MA) presented a new approach 25 to reducing hyperactive TGF-β signaling in fibrotic kidney disease. He shared preclinical data for a …

Jan 3, 2022 · Bintrafusp Alfa, a novel fusion protein designed to target the transforming growth factor beta (TGFβ) pathway, racked up 3 clinical trial disappointments in less than a year,...

provide the rationale for alternative targeting strategies of TGF -β signaling as potential approaches in CKD therapy. Selective inhibition of TGF-β signaling modulators to fine-tune …

For efficient and accurate gravity forward modelling in the spatial domain, we developed a new MATLAB-based program called, terrain gravity field (TGF). Our new software is capable of …

Jul 5, 2024 · This review first analyzes normal TGF-β signaling and then investigates its role in CRC pathogenesis, highlighting the mechanisms through which TGF-β influences metastasis …