Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-spanning receptors usually expressed on sentinel cells such as macrophages …

Toll 样受体 4 （Toll-like receptor 4，TLR4）是由 Poltorak 等于 1998 年发现的 一种 I 型跨膜蛋白，其由 TLR4 基因编码，并表达于包括单核细胞，巨嗜细胞在内 的多种组织细胞中，可以识 …

The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. …

2024年1月22日 · 以下是tlr4的几个关键功能：识别lps： tlr4与共受体md-2结合，形成一个复合体，可以有效地识别和结合lps。 信号传导： 识别LPS后，TLR4复合体通过两种不同的途径传递 …

2013年12月6日 · In this review, we summarize these structures and describe the structural basis of LPS recognition by LPS receptors and accessory proteins. In the initial phase of infection, …

TLR4 has now been established as the receptor for LPS; however, in addition to this, TLR4 also recognizes lipoteichoic acid (LTA), fibronectin, the fusion protein of respiratory syncytial virus …

1999年4月16日 · TLR4 is a member of the recently identified Toll-like receptor family of proteins and has been putatively identified as Lps, the gene necessary for potent responses to …

TLRs are important receptors involved in innate immunity, and they can specifically identify and combine pathogen-associated molecular patterns (PAMPs), triggering a series of signal …

1978年，James Watson首次提出小鼠体内可能存在控制LPS反应的特定基因，取名为Lps，认为该基因可能有两个等位基因：即Lpsd（defective response〉和Lpsn（normal response）。三 …

2012年6月8日 · TLR2 plays a dual role in the induction of intracellular signals that impair MTAL function, both through cooperation with TLR4 to mediate ERK signaling by LPS and through a …