A family of Toll-like receptors (TLRs) acts as primary sensors that detect a wide variety of microbial components and elicit innate immune responses. All TLR signaling pathways culminate in activation of the transcription factor nuclear factor-kappaB (NF-kappaB), which controls the expression of an array of inflammatory cytokine genes.

tlr/myd88/nf-κb信号通路是机体炎症体系中的重要途径，其广泛存在于各种组织细胞中，参与多种疾病的发生与调控，如自身免疫性疾病、炎症性疾病、感染性疾病、过敏性疾病等。toll样受体(tlr)是一种跨膜蛋白，能够识别多种类型的病原相关分子模式(如脂多糖、尿酸钠晶体、病毒双链rna等)，引起机体 ...

All TLR signaling pathways culminate in activation of the transcription factor nuclear factor-kappaB (NF-κB), which controls the expression of an array of inflammatory cytokine genes. NF-κB activation requires the phosphorylation and degradation of inhibitory κB (IκB) proteins, which is triggered by two kinases, IκB kinase α (IKKα) and ...

NLRP3抑制TNF-alpha，TNF-alpha诱导RELA/NF-KB p65的激活和核转运。 ... TLR刺激触发MyD88与IRAK4(白细胞介素-1受体相关激酶4)相互作用，传递信号到NF-κB和MAPK，通过MyD88-依赖途径激活炎症因子的表达。内体TLRs通过TRIF-依赖的通路传递信号。

2024年3月4日 · NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses. ... and involved in TLR-stimulated NF ...

2020年2月21日 · TLR7 and TLR8 Differentially Activate the IRF and NF-κB Pathways in Specific Cell Types to Promote Inflammation Immunohorizons. 2020 Feb 21 ... How the roles of TLR7 and TLR8 differ may be determined by which cell types express each TLR and how the cells respond to activation of each receptor. To provide a better understanding of the effects ...

Elucidating new targets within the TLR signaling cascades has important implications for anti-inflammatory strategies aimed at inhibiting NF-κB transcription in human disease states where ...

Toll样受体（Toll-like receptor，TLR）家族是宿主细胞识别各种微生物致病成份的主要受体，NF-kB位于TLR下游信号通路的枢纽位置，当细胞受到生物应激刺激后激活NF-kB，活化的NF-kB进入细胞核调节炎性细胞因子的表达，启动针对病原微生物的固有免疫和获得性免疫。

TLR4/NF-κB/NLRP3 通路抑制炎症反应作用的研究 ... cerebral ischemia-reperfusion injury and subsequently expressed in neurons and microvascular endothelial cells.The TLR/NF-κB/NLRP3 signaling pathway,which is activated by TLRs,transmitted by NF-κB and activated by NLRP3,plays a key role in the inflammatory response of various ...

普遍转录的四肽重复x染色体是干细胞表型的重要调节因子。li等在sci小鼠nscs中敲除utx后发现，nscs可显著抑制nf-κb信号的激活，促进巨噬细胞迁移抑制因子的分泌，诱导初始状态的巨噬细胞向m2型极化，减少sci后的瘢痕增生。