Toll-like receptor 10 is a protein that in humans is encoded by the TLR10 gene. [3] TLR10 has also been designated as CD290 (cluster of differentiation 290). TLR10 has not been extensively studied because it is a pseudogene in mice, though all other mammalian species

TLR10 is the only known member of TLR family that can elicit anti-inflammatory effect. TLR10 can inhibit other TLRs by competing with stimulatory TLRs, dimerising with TLR1, TLR2 and TLR6, and by inducing PI3K/Akt to produce IL-1Ra.

Studies have revealed that TLR10 is found on the same gene cluster with TLR1 and TLR6 and is also a coreceptor of TLR2. Up to date, TLR10 is the only TLR which exhibit anti-inflammatory property. Previously, TLR10 was thought to be an “orphan receptor” but much recent studies have identified ligands for TLR10.

2014年10月6日 · We demonstrate the biological role of TLR10, the only member of the Toll-like receptor (TLR)-family so far without a known function. We show that TLR10 acts as an inhibitory receptor, with suppressive effects. Blocking TLR10 by specific antibodies significantly upregulated TLR2-mediated cytokine production.

2024年1月22日 · 人类有至少10种不同的Toll样受体，它们分别是TLR1到TLR10。 这些受体在细胞表面或内部细胞器（如 内质网 、 内体 和 溶酶体）上有不同的表达和定位，可以识别不同的PAMPs和DAMPs，其中TLR1, TLR2, TLR4, TLR5, TLR6, 和 TLR10 主要表达在细胞表面，参与识别细菌、真菌和某些病毒的组成成分；TLR3, TLR7, TLR8, 和 TLR9 主要位于内质网、内体和溶酶体，识别核酸类分子，比如病毒的RNA和DNA。 TLR1: TLR1是人类的Toll样受体之一，与其 …

TLR是一类定位在膜上的模式识别受体，在人类中具有10种（TLR1-TLR10）在小鼠中具有12种（TLR1-TLR9，TLR11-TLR13）。 该家族蛋白均为糖蛋白，N端为朝向胞外（或endosome腔内）具有底物结合能力的Leucine-rich repeat（LRR），而另一侧则是负责将信号转导入胞内的Toll/interleukin-1 (IL-1) receptor homology (TIR)结构域（图1）。 1996年，Jules A. Hoffmann实验室发现Toll信号通路在果蝇成虫中控制抗真菌感染中至关重要的果蝇霉素（drosomycin）的表 …

2024年12月25日 · TLR10 (Toll Like Receptor 10) is a Protein Coding gene. Diseases associated with TLR10 include Melioidosis and Inflammatory Bowel Disease 20. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll-Like receptor Signaling Pathways.

2020年10月12日 · Polymorphisms in the TLR10 gene can change the balance between pro- and anti-inflammatory responses and hence modulate the susceptibility to infection and autoimmune diseases. Understanding the full range of TLR10 ligands and functions may allow the receptor to be exploited as a therapeutic target in inflammation- or immune-related diseases.

2025年2月8日 · TLR10 is a modulatory pattern-recognition receptor with mainly inhibitory properties; Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection. CCL20, CCL1, & IL-8 were reduced following TKR10 knockdown. TLR10 silencing increased viability of L. monocytogenes in both HT-29 & THP-1 cells.

Understanding the full range of TLR10 ligands and functions may allow the receptor to be exploited as a therapeutic target in inflammation- or immune-related diseases. Here, we summarize recent findings on the pro- and anti-inflammatory roles of TLR10 and the molecular pathways in which it is implicated.