TLR4/MyD88/NF-κB signaling participates in the inflammatory response of the myocardium after CME, activating the NLRP3 inflammasome, promoting the inflammatory cascade, and aggravating myocardial injury. Blocking TLR4/MyD88/NF-κB signaling may help reduce myocardial injury and improve cardiac functi …

2021年5月15日 · Western blot分析结果显示，葛根素能够明显下调MI/R损伤大鼠心肌TLR4、Myd88及NLRP3、凋亡相关斑点样蛋白（apoptosis-associated speck-like protein containing a CARD，ASC）、切割型半胱氨酸天冬氨酸蛋白酶-1（cleaved-caspase 1）、切割型gasdermin-D（cleaved-GSDMD）、IL-1 β 、IL-18蛋白水平 ...

2024年12月30日 · NLRP3通过抑制TNF-alpha的活性，可以间接地影响NF-KB信号通路的激活状态。 在NLRP3炎症小体的激活过程中，存在两个关键的步骤：启动和激活。 启动阶段通常由内源性细胞因子或微生物分子触发，这些分子能够诱导NLRP3的表达和预组装。

Activation of TLR4 by DAMPs causes an inflammatory response in myocardial tissue, producing additional damage to the already damaged cardiomyocytes. 11,12 Previous reports have shown that myocardial inflammation is reduced by TLR4/Myd88/NF-κB pathway inhibition, improving cardiac function.

2016年10月10日 · Curcumin also markedly inhibited the upregulation of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), phosphorylation level of IκB-α, and activation of NF-κB in PMA-induced macrophages.

NLRP3/Cas-1 modulators could selectively suppress inflammation caused by the NLRP3 inflammasome, either by directly targeting NLRP3 and NLRP3-dependent pathways (NF-kB pathway and ROS synthesis) or by inhibiting regulatory proteins involved in PD neurodegeneration, such as caspase-1 .

2023年10月1日 · The interplay between Aβ, Toll-like receptor 4 (TLR4), NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, and interleukin-1β (IL-1β) within microglia establishes a self-sustaining cycle of Aβ-triggered neuroinflammation in AD.

2021年7月1日 · Our results suggest that PLD attenuate LPS-induced ALI by inhibiting NLRP3-type inflammatory microsomes, the mechanism is dependent on the TLR4/MyD88/NF-kB signaling pathway. Excessive inflammatory reaction is a key factor in the pathogenesis of ALI, which can lead to the increase of capillary permeability, the infiltration of massive ...

Suppression of NLRP3 inflammasome by Platycodin D via the TLR4/MyD88/NF-κB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats

Given the effect of curcumin on the expression of NLRP3 inflammasome and regulation of TLR4/MyD88/NF-κB and P2X7R, we concluded that curcumin reduced NLRP3 inflammasome, cleaved caspase-1 induction, and consequently reduced IL-1β secretion through TLR4/MyD88/NF-κB and P2X7R pathways in PMA-induced macrophages; the schematic model is …