The SYK side of TLR4: signalling mechanisms in response to LPS …
Recent data point to constitutive binding of SYK to the cytoplasmic domain of toll-like receptor-4 (TLR4). This SYK-TLR4 binding increases upon TLR4 dimerization and phosphorylation, and …
The Tyrosine Kinase Syk Differentially Regulates Toll-like ... - AAAS
2013年8月20日 · We found that the nonreceptor tyrosine kinase Syk partially mediated the endocytosis of TLR4, but it also played a dual role in TLR4-mediated signaling. LPS …
A Novel TLR4-SYK Interaction Axis Plays an Essential Role in the …
2022年12月30日 · In this study, for the first time, in vivo, TLR4 and SYK were colocalized and had a high correlation in mastitis mammary epithelium; protein−protein interaction results also …
Syk Negatively Regulates TLR4-mediated IFNβ and IL-10 …
The function of Syk in the regulation of TLR4-mediated production of IFNβ and inflammatory cytokines is controversial. Here, we demonstrate that deficiency of Syk enhances the …
A Novel TLR4-SYK Interaction Axis Plays an Essential Role in the …
2022年12月30日 · To investigate the correlation of SYK and TLR4 in the innate immunity response of bMECs, this study focuses on the differential expression of SYK and TLR4 before …
跨膜接头 SCIMP 募集酪氨酸激酶 Syk 磷酸化 Toll 样受体以介导选 …
在这里，我们显示 scimp 招募 syk 以响应脂多糖介导的 tlr4 激活。 我们还表明 Syk 有助于 SCIMP 和 TLR4 的磷酸化以增强它们的结合。 进一步的证据表明 SCIMP 中的两个特定磷酸化位点对 …
Syk negatively regulates TLR4-mediated IFNβ and IL-10 ... - PubMed
Syk deficiency resulted in decreased phosphorylation of IKKβ and the NF-κB p65 subunit, further suggesting a divergent influence of Syk on pro- and anti-inflammatory TLR responses. …
TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives …
2019年10月10日 · SYK constitutively binds to the cytoplasmic Toll/interleukin-1 receptor domain of TLR4 26 and plays a prominent role in TLR4 signaling in response to minimally modified …
An examination of the LPS-TLR4 immune response through the …
2025年3月18日 · The LPS-TLR4 immune response is a critical mechanism in the body's defense against Gram-negative bacterial infections, yet its dysregulation can lead to severe …
The SYK side of TLR4: signalling mechanisms in response to LPS …
Recent data point to constitutive binding of SYK to the cytoplasmic domain of toll-like receptor-4 (TLR4). This SYK-TLR4 binding increases upon TLR4 dimerization and phosphorylation, and …