TLR7/8激动剂有望重塑肿瘤免疫赛道新规则 - 知乎
2020年12月8日，Nature Cancer期刊在线发表了题为Immune-stimulating antibody conjugates elicit robust myeloidactivation and durable antitumor immunity的研究，该研究介绍了一种抗体 …
Targeting toll-like receptor 7/8 for immunotherapy: recent …
2022年12月7日 · The wide range of expression and clinical significance of TLR7/TLR8 in different kinds of cancers have been extensively explored. TLR7/TLR8 can be used as novel diagnostic …
下一代疫苗佐剂： TLR激动剂 - 知乎
2023年9月12日 · TLR7/8识别单链核糖核酸（ssRNA），并通过MyD88依赖性途径发出信号。 在天然配体中，富含腺苷和尿苷的寡核苷酸（ORN）能够激活TLR8，而对TLR7没有任何影响， …
Agonist and antagonist ligands of toll-like receptors 7 and 8 ...
TLRs 7/8 are located in the endosomal compartment and activate a specific signaling pathway in a MyD88-dependant manner. According to their involvement into various autoimmune, …
Recent trends in the development of Toll-like receptor 7/8
TLR7/8 agonists exhibit potent antiviral activity and regulate anti-tumor immune responses. TLR7 agonists have also been used as adjuvants to improve vaccine immunogenicity and generate …
清华大学廖学斌团队发现新型TLR7/8双激动剂，具有显著的抗肿瘤 …
2021年6月9日 · 基于结构的新型骨架的 TLR7/8 双激动剂的设计 在体外，化合物 24e 和 25a 在人外周血单核细胞试验中显著诱导了细胞因子IFN-α、IFN-γ、TNF-α、IL-1β、IL-12p40和IP-10 …
Targeting toll-like receptor 7/8 for immunotherapy: recent
2022年12月7日 · TLR7/TLR8 can be used as novel diagnostic biomarkers, progression and prognostic indicators, and immunotherapeutic targets for various tumors. Although the …
TLR7 and TLR8 Differentially Activate the IRF and NF-κB ... - PubMed
2020年2月21日 · TLR7 and TLR8 are pattern recognition receptors that reside in the endosome and are activated by ssRNA molecules. TLR7 and TLR8 are normally part of the antiviral …
Evolution of Toll-like receptor 7/8 agonist therapeutics and their ...
2021年8月1日 · In addition to inducing an antiviral state through secretion of type I interferons (IFNs), synthetic TLR7/8 agonists trigger acute inflammation and stimulate adaptive immunity …
<br>靶向 Toll 样受体 7/8 的免疫治疗：最新进展和前景,Biomarker …
2022年12月7日 · TLR 激动剂可以通过先天性和适应性免疫反应激活 T 细胞介导的抗肿瘤反应，从而改善肿瘤治疗。 最近，已经开发出具有不同支架的TLR7或TLR8激动剂的新药物。 这些激 …