2021年5月29日 · Tenascin-C (TNC) 是一种大的细胞外基质糖蛋白，可促进细胞粘附和组织重塑，并参与细胞信号通路的转导。 本研究旨在研究 TNC 的作用并确定其在鼻咽癌 (NPC) 中的作用。 使用NPC数据集和NPC组织的免疫组织化学分析来分析TNC基因的转录和表达。 进行加权基因共表达网络和基因富集分析，以确定 TNC 对 NPC 影响的潜在分子机制。 TNC 表达在 NPC 细胞中受到抑制，其影响在体外和体内均已确定. 结果表明，与正常组织相比，NPC 组织中的 TNC …

Tenascin-C (TNC) is a large extracellular matrix glycoprotein that promotes cell adhesion and tissue remodeling, and is involved in the transduction of cellular signaling pathways. The present study aimed to investigate the role of TNC and determine its effect in …

Tenascin-C (TNC) is a large extracellular matrix glycoprotein that promotes cell adhesion and tissue remodeling, and is involved in the transduction of cellular signaling pathways. The present study aimed to investigate the role of TNC and determine its effect in …

2023年4月10日 · TNC overexpression in fibroblasts boosts neurite outgrowth in co-cultured neurons, while fibroblast-specific TNC ablation suppresses hyperinnervation and alleviates skin inflammation in male...

2021年12月1日 · SMY may restore its original DNA methylation status, and thus, enhance radiosensitivity. Furthermore, we confirmed that the differential gene Tenascin-C (TNC) was overexpressed in CNE-2R cells and that SMY downregulated TNC expression. This downregulation of TNC inhibited NPC cell radiation resistance, migration, and invasion.

SMY may restore its original DNA methylation status, and thus, enhance radiosensitivity. Furthermore, we confirmed that the differential gene Tenascin-C (TNC) was overexpressed in CNE-2R cells and that SMY downregulated TNC expression. This downregulation of TNC inhibited NPC cell radiation resistance, migration, and invasion.

(C) Immunohistochemical staining of TNC in clinical NPC and NPG tissues. Tissues were classified as −, +, ++ and +++. Brown staining represents TNC protein expression, while blue staining ...

2024年1月1日 · Tenascin-C (TNC) is a multimodular extracellular matrix (ECM) protein hexameric with several molecular forms (180-250 kDa) produced by alternative splicing at the pre-mRNA level and protein modifications. The molecular phylogeny indicates that the amino acid sequence of TNC is a well-conserved protein among vertebrates.

Tenascin C (TNC), a matricellular protein, is a hexameric and multimodular glycoprotein with different molecular forms that is produced by alternative splicing and post-translational modifications. Malignant gliomas are the most common and aggressive primary brain cancer of the central nervous system.

2025年2月11日 · 常见的三电平拓扑结构有I型NPC、ANPC和T型NPC，它们在不同应用场景中各有特点和优缺点。 1. I型NPC（Neutral Point Clamped） 结构：I型NPC是最早提出的一种三电平拓扑，其基本结构由两级逆变器电路组成，使用两个中间电压点（中性点）来分配电压。 电源通过多个开关（通常是IGBT）控制三个电平：正电压、中性电压、负电压。 工作原理：I型NPC利用中性点将输出电压分为三个电平。 这种结构在每个开关元件的承受电压较低的情况下，提供了 …