2019年9月18日 · In this study, we characterized the prosurvival role of A20 in cells exposed to TNF, and evaluated some of our in vitro findings in an in vivo model of lethal inflammation induced by the ...

We show here that the zinc finger protein A20 is an NF-κB-inducible gene that can protect the IKKγ-deficient cells from TNF-induced apoptosis by disrupting the recruitment of the death domain signaling molecules TRADD and RIP to the receptor signaling complex.

2001年4月23日 · A20 is a primary response gene that encodes an 80 kDa protein, whose C-terminus consists of seven Cys 2 /Cys 2 zinc fingers. 19,20 A20 effectively inhibits TNF- and interleukin-1β (IL-1β ...

2020年9月21日 · A20, also known as TNF-α-induced protein 3 (TNFAIP3), is an anti-inflammatory protein that plays an important part in both immune responses and cell death. Impaired A20 function is associated with several human inflammatory and autoimmune diseases.

In this study, we demonstrated that A20 (also known as TNFAIP3, tumor necrosis factor α-induced protein 3, and an anti-apoptotic protein) regulates the inhibitor of apoptosis protein-2 (cIAP-2) expression upon TNF-α induction in endothelial cells.

The zinc finger protein A20 is a tumor necrosis factor (TNF)– and interleukin 1 (IL-1)-inducible protein that negatively regulates nuclear factor-kappa B (NF-κB)–dependent gene expression. However, the molecular mechanism by which A20 exerts this ...

2004年10月15日 · A20 is a zinc finger protein originally identified as a tumor necrosis factor (TNF)–responsive gene in endothelial cells (ECs). 1 A20 is expressed in multiple cell types in response to a variety of stimuli that activate the transcription factor nuclear factor–κB (NF-κB), including interleukin 1 (IL-1), lipopolysaccharide (LPS), phorbol 12 ...

2025年2月7日 · A20的锌指结构域与肿瘤坏死因子（tumor necrosis factor，TNF）信号通路中的蛋白，如受体相互作用蛋白1（receptor interacting protein 1, RIP1），相互作用，抑制其泛素化，减少TNF诱导的细胞凋亡 [8] 。A20通过抑制NOD样受体热蛋白结构域相关蛋白3炎症小 …

2019年9月18日 · In the present study, we provide in vitro and in vivo evidences that deletion of A20 induces RIPK1 kinase-dependent and -independent apoptosis upon single TNF stimulation. We show that constitutively expressed A20 is recruited to TNFR1 signaling complex (Complex I) via its seventh zinc finger (ZF7) domain, in a cIAP1/2-dependent manner, within ...

A20 zinc finger protein is a negative regulator of tumor necrosis factor (TNF)-induced signaling pathways leading to apoptosis, stress response and inflammation. A20 has been shown to bind to TNF-receptor-associated factor 2 (TRAF2) and 14-3-3 chaperone proteins.