[TNF-α activates PI3K/AKT pathway to promote proliferation of …
The inflammatory microenvironment of Lgr5 + CSCs was established with TNF-α and the optimum conditions of TNF-α were analyzed using CCK-8 assay. CSCs were treated with PI3K/AKT …
PI3K-Akt信号通路详解：通路激活+通路组成+通路串联+通路检 …
PI3K-Akt信号通路是细胞中一个关键的信号传导网络，它可被多种细胞刺激或毒性损伤所激活，并在调控转录、翻译、增殖、生长和存活等基本细胞功能中扮演重要角色。 当生长因子与细胞 …
经典的TNF信号通路 - 知乎 - 知乎专栏
TNF （Tumor Necrosis Factor）又称TNFα，是一种能直接杀伤肿瘤细胞且对正常细胞无明显细胞毒性的细胞因子，是一种参与全身炎症的细胞信号蛋白，是构成急性期反应的细胞因子之一。
TNF-α signals through ITK-Akt-mTOR to drive CD4 - Science
2024年4月23日 · These data suggest that cell-intrinsic TNF-α stimulates the activity of Akt-mTOR during CD4 + T cell activation, which requires ITK but not Jak1 or Jak2, and that Akt activity is …
TNF-alpha stimulates Akt by a distinct aPKC-dependent pathway …
Tumor necrosis factor-alpha (TNF-alpha) is an important proinflammatory cytokine involved in the pathogenesis of inflammatory skin diseases and cutaneous squamous cell carcinoma. Some …
TNFα 和 IFNγ 快速激活 PI3K-AKT 信号传导以驱动糖酵解，从而赋 …
TNFα 和 IFNγ 治疗导致 MSCs 中葡萄糖的快速消耗和代谢偏向糖酵解，这是 MSCs 对 IBD 的治疗效果所必需的。 阻断间充质干细胞中的糖酵解可抑制免疫调节分子 IDO 和 TSG-6 的表达，以 …
Frontiers | Regulation of PI-3-Kinase and Akt Signaling in T ...
2013年6月6日 · Activation of phosphoinositide 3-kinase (PI3K) and Akt (protein kinase B) is a common response triggered by a range of membrane-bound receptors on many cell types. In …
摩罗丹浓缩丸通过TNF/PI3K/AKT信号通路治疗慢性萎缩性胃炎
2024年11月29日 · ppi网络分析显示，tnf和akt1可能是mld治疗cag的关键靶点。tnf是一种由巨噬细胞分泌产生的炎症细胞因子。一定含量的tnf对机体具有保护作用，可使机体免受病原体侵 …
TNF-α increases lipogenesis via JNK and PI3K/Akt pathways in …
Involvement of c-Jun N-terminal kinase (JNK) and Akt in TNF-α-induced lipogenesis was investigated by molecule specific small interfering RNA and inhibitors. Results: TNF-α …
Macrophages induce AKT/β-catenin-dependent Lgr5 - Nature
2017年3月27日 · Here we show that macrophages in wounds activate HF stem cells, leading to telogen–anagen transition (TAT) around the wound and de novo HF regeneration, mostly …