TNF-α producing cells are the dominant population of hepatitis B virus (HBV)-specific CD4 T cells in patients with chronic HBV infection. This population of cells might contribute to the aggravation of liver damage in patients with a hepatitis B flare. HBV-specific IFN-γ producing CD4 T …

2018年1月29日 · The role of TNF in HBV clearance is evidenced not only by impaired T cell responses against HBV and prolonged viral persistence in TNF receptor-1 (TNFR1) knockout mice 3 and TNF-α...

Chronic hepatitis B virus (HBV) infection is a major risk factor of hepatocellular carcinoma (HCC), and HBV-specific CD8 T cells could exert anti-tumor roles in HCC patients. Here, we found that HBV-specific CD8 T cells, both in the peripheral blood and in the tumor microenvironment, were more enriched with TNF-α-expressing cells than ...

慢性hbv感染患者中，tnf-α产生的细胞是hbv特异性cd4 t细胞的主要群体，该细胞群可能会加重hbv暴发患者的肝损伤。 产生HBV特异性IFN-γ的CD4 T细胞与HBV病毒清除相关。

Tumor necrosis factor alpha (TNF-α) is associated with noncytopathic clearance of hepatitis B virus in animal models. Here we demonstrate that the nuclear factor κB (NF-κB) signaling pathway is a central mediator of inhibition of hepatitis B virus by TNF-α …

国产重组人Ⅱ型tnf受体－抗体融合蛋白(rh tnfr：fc)属于生物类似物，是我国第一个上市且应用最广的tnf－α拮抗剂之一，其对spa患者hbv感染状态的影响目前尚未见大样本前瞻性报道。

Expert opinion: In hepatitis B surface antigen (HBsAg) carriers undergoing anti-TNF therapy, either anti-HBV treatment or prophylaxis is mandatory to prevent hepatitis reactivation, whereas HBsAg-negative antibody to hepatitis B core antigen (anti-HBc) seropositive patients require watchful monitoring, only. Conversely, in HCV-infected patients ...

Tumor necrosis factor (TNF)-α is a key cytokine not only in the pathogenesis of autoimmune diseases but also in the host immune reactions against HBV infection. TNF-α is synthesized by macrophages and T cells and induce the production of a variety of inflammatory cytokines, suppressing viral replication.

Hepatitis B reactivation (HBVR) is an important risk of treatment with tumor necrosis factor inhibitors (anti-TNF). While antiviral prophylaxis is recommended before treatment in hepatitis B surface antigen (HBsAg) positive patients, there is no ...

Recently, a high rate of HBV reactivation in individuals receiving tumor necrosis factor‐α (TNF‐α) antagonists showed the importance of this cytokine in HBV infection control. Here, we investigated the influence of TNF‐α promoter polymorphisms on susceptibility to chronic HBV infection (CHB), liver injury progression and outcomes.

2020年7月6日 · Phenotyping of hepatitis B virus (HBV)‐specific tumor necrosis factor (TNF)‐α‐expressing CD8 T cells. (a) CD8 T cells were stimulated via pan‐T cell activation or HBV‐specific peptides. Expression of CD45RO, tumor necrosis factor receptor 1 (TNF‐R1) and TNF‐R2 was shown in one representative individual.

The role of TNF in HBV clearance is evidenced not only by impaired T cell responses against HBV and prolonged viral persistence in TNF receptor-1 (TNFR1) knockout mice 3 and TNF-α blockaded model mice, 1 but also by the genetic studies, in which TNF-α gene polymorphisms, in particular the promoter region, affect susceptibility to chronicity ...

2020年1月1日 · TNF-α producing cells are the dominant population of HBV-specific CD4 T cells in chronic HBV infection. Increased frequency/dominance of HBV-specific IFN-γ producing CD4 T cells parallels elevated HBV viral clearance. HBV core-specific TNF-α producing CD4 T cells are associated with liver damage in patients with a hepatitis B flare.

2018年6月18日 · Tumor necrosis factor receptor superfamily 2 (TNFR2) plays an important role in controlling the progression of antiviral and antitumorr. Evidence suggests that TNFR2 is involved in the...

2015年2月9日 · In this study, HBV clearance and T-cell responses were analyzed in a HBV-transfected mouse model under anti-TNF blockage therapy. Our results demonstrated that under TNF-α blockage therapy,...

2014年7月21日 · In this study, our results demonstrate that the HBV core is critical for inducing TNF-α and enhancing the clearance of HBV. In addition, TNF blockage abolished the HBV core-induced viral clearance effects in mice, suggesting that host innate immunity senses the HBV core through the innate immune sensor and induces TNF-α.

2014年7月7日 · Antitumor necrosis factor-alpha (TNF- α) agents are widely used for treatment of rheumatic and dermatological diseases. We conducted the systematic review and meta-analysis to assess the prevalence of HBV reactivation among patients treated with anti-TNF- α. …

The use of anti-TNF in patients with past HBV infection has a low risk for HBVR. A follow-up for the ALT and HBV DNA levels at 3-month intervals may be more reasonable than administering antiviral prophylaxis to all patients.

3 天之前 · Background: The MeMed BV® BV score is a novel, promising host-protein score, differentiating bacterial from viral infections, that combines the expression levels of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10 (IP-10), and C-reactive protein (CRP). The aim of our study was to determine its diagnostic accuracy in hospitalized febrile ...

Within 6 months before the initial anti-TNF-α therapy, performing a HBsAg and/or anti-HBc test is defined as HBV screening. HBV reactivation is defined as the presence of detectable serum HBV DNA or HBsAg seroconversion from negative to positive. Results: The overall HBV screening rate was 82.3% before starting anti-TNF-α therapy.