2018年11月15日 · Here we showed that c-Jun N-terminal kinases (JNK1 and JNK2) displayed kinase-dependent and -independent functions in regulating TNF- and TLRs-mediated necroptosis. We found that RIPK1 and RIPK3...

Three groups of MAP kinases can be defined: ERK (extracellular signal-regulated kinase); JNK (c-Jun N-terminal kinase); and p38 MAP kinases. These pathways can be activated by many stimuli, including growth factors, inflammatory cytokines, and a wide spectrum of cellular stresses.

The binding of tumour necrosis factor α (TNFα) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun …

2021年12月1日 · We report that JNK has a dual role in the TNF-stimulated death of fibroblasts. JNK can suppress TNF-stimulated apoptosis, but can also potentiate TNF-stimulated necrosis. The increased necrosis is mediated, in part, by a requirement of JNK for TNF-induced production of cytotoxic reactive oxygen species (ROS).

2005年1月1日 · JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation contributes to TNF-α induced...

2012年1月18日 · 来自芝加哥大学，中科院上海生物化学与细胞生物学研究所的研究人员发表了题为“Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α–induced JNK activation and inflammation”的文章，获得了TNF-α-JNK 信号通路研究的最新成果，这一成果公布在美国《国家科学院院刊》（PNAS）杂志上。 文章的通讯作者是生物化学与细胞生物学研究所的林安宁教授，他是细胞信号转导领域的国际知名学者、芝 …

2003年10月3日 · Tumor necrosis factor (TNFalpha) receptor signaling can simultaneously activate caspase 8, the transcription factor, NF-kappaB and the kinase, JNK. While activation of caspase 8 is required for TNFalpha-induced apoptosis, and induction of NF-kappaB inhibits cell death, the precise function of JNK ac …

2004年2月20日 · TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFκB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood.

2013年11月15日 · 我们发现许多类型的 aml 产生 tnf，这种 tnf 以自分泌方式通过 nf-κb 和 jnk-ap1 的平行激活促进 lsc 存活和自我更新，以及以旁分泌方式抑制正常造血. 所以，我们建议同时抑制 TNF-JNK-AP1 和 NF-κB 信号可能为外周血 TNF 升高的 AML 患者提供更彻底的治疗。

TNF-JNK信号转导通路在细胞增殖、分化、迁移、凋亡及应激反应中起着重要作用，并与肿瘤、神经退行性疾病和免疫缺陷等重大疾病的发生与发展密切相关。 泛素化作为蛋白翻译后修饰的主要调节方式之一，参与调控细胞周期、DNA损伤修复、免疫应答及信号转导。 目前，泛素化在TNF-JNK信号通路中的调控作用及机制仍不清楚。 我们以果蝇为模式动物，证明在眼中过表达TNF可激活JNK信号通路介导的细胞凋亡并产生小眼表型。 我们利用此表型对全基因组进行了遗传筛 …