
c-Jun N-terminal kinases differentially regulate TNF- and TLRs …
2018年11月15日 · Here we showed that c-Jun N-terminal kinases (JNK1 and JNK2) displayed kinase-dependent and -independent functions in regulating TNF- and TLRs-mediated necroptosis. We found that RIPK1 and RIPK3...
TNF and MAP kinase signaling pathways - PMC - PubMed …
Three groups of MAP kinases can be defined: ERK (extracellular signal-regulated kinase); JNK (c-Jun N-terminal kinase); and p38 MAP kinases. These pathways can be activated by many stimuli, including growth factors, inflammatory cytokines, and a wide spectrum of cellular stresses.
TNF and MAP kinase signalling pathways - PubMed
The binding of tumour necrosis factor α (TNFα) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun …
JNK potentiates TNF-stimulated necrosis by increasing the …
2021年12月1日 · We report that JNK has a dual role in the TNF-stimulated death of fibroblasts. JNK can suppress TNF-stimulated apoptosis, but can also potentiate TNF-stimulated necrosis. The increased necrosis is mediated, in part, by a requirement of JNK for TNF-induced production of cytotoxic reactive oxygen species (ROS).
Role of JNK activation in apoptosis: A double-edged sword
2005年1月1日 · JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation contributes to TNF-α induced...
TNF-α-JNK信号通路研究获进展 - 科学网
2012年1月18日 · 来自芝加哥大学,中科院上海生物化学与细胞生物学研究所的研究人员发表了题为“Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α–induced JNK activation and inflammation”的文章,获得了TNF-α-JNK 信号通路研究的最新成果,这一成果公布在美国《国家科学院院刊》(PNAS)杂志上。 文章的通讯作者是生物化学与细胞生物学研究所的林安宁教授,他是细胞信号转导领域的国际知名学者、芝 …
A JNK-dependent pathway is required for TNFalpha-induced …
2003年10月3日 · Tumor necrosis factor (TNFalpha) receptor signaling can simultaneously activate caspase 8, the transcription factor, NF-kappaB and the kinase, JNK. While activation of caspase 8 is required for TNFalpha-induced apoptosis, and induction of NF-kappaB inhibits cell death, the precise function of JNK ac …
Tumor Necrosis Factor - Cell Press
2004年2月20日 · TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFκB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood.
AML 细胞利用 TNF 驱动的 JNK 信号作为关键的 NF-κB 独立生存 …
2013年11月15日 · 我们发现许多类型的 aml 产生 tnf,这种 tnf 以自分泌方式通过 nf-κb 和 jnk-ap1 的平行激活促进 lsc 存活和自我更新,以及以旁分泌方式抑制正常造血. 所以,我们建议同时抑制 TNF-JNK-AP1 和 NF-κB 信号可能为外周血 TNF 升高的 AML 患者提供更彻底的治疗。
泛素化修饰在TNF-JNK信号转导通路中的调控作用及机制研究
TNF-JNK信号转导通路在细胞增殖、分化、迁移、凋亡及应激反应中起着重要作用,并与肿瘤、神经退行性疾病和免疫缺陷等重大疾病的发生与发展密切相关。 泛素化作为蛋白翻译后修饰的主要调节方式之一,参与调控细胞周期、DNA损伤修复、免疫应答及信号转导。 目前,泛素化在TNF-JNK信号通路中的调控作用及机制仍不清楚。 我们以果蝇为模式动物,证明在眼中过表达TNF可激活JNK信号通路介导的细胞凋亡并产生小眼表型。 我们利用此表型对全基因组进行了遗传筛 …
- 某些结果已被删除