c-Jun N-terminal kinases differentially regulate TNF- and TLRs …
2018年11月15日 · Here we showed that c-Jun N-terminal kinases (JNK1 and JNK2) displayed kinase-dependent and -independent functions in regulating TNF- and TLRs-mediated …
TNF and MAP kinase signaling pathways - PMC - PubMed …
Three groups of MAP kinases can be defined: ERK (extracellular signal-regulated kinase); JNK (c-Jun N-terminal kinase); and p38 MAP kinases. These pathways can be activated by many …
TNF and MAP kinase signalling pathways - PubMed
The binding of tumour necrosis factor α (TNFα) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: …
JNK potentiates TNF-stimulated necrosis by increasing the …
2021年12月1日 · We report that JNK has a dual role in the TNF-stimulated death of fibroblasts. JNK can suppress TNF-stimulated apoptosis, but can also potentiate TNF-stimulated necrosis. …
Role of JNK activation in apoptosis: A double-edged sword
2005年1月1日 · JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation contributes to TNF …
TNF-α-JNK信号通路研究获进展 - 科学网
2012年1月18日 · 来自芝加哥大学，中科院上海生物化学与细胞生物学研究所的研究人员发表了题为“Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated …
A JNK-dependent pathway is required for TNFalpha-induced …
2003年10月3日 · Tumor necrosis factor (TNFalpha) receptor signaling can simultaneously activate caspase 8, the transcription factor, NF-kappaB and the kinase, JNK. While activation …
Tumor Necrosis Factor - Cell Press
2004年2月20日 · TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFκB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis …
AML 细胞利用 TNF 驱动的 JNK 信号作为关键的 NF-κB 独立生存 …
2013年11月15日 · 我们发现许多类型的 aml 产生 tnf，这种 tnf 以自分泌方式通过 nf-κb 和 jnk-ap1 的平行激活促进 lsc 存活和自我更新，以及以旁分泌方式抑制正常造血. 所以，我们建议同时 …
泛素化修饰在TNF-JNK信号转导通路中的调控作用及机制研究
TNF-JNK信号转导通路在细胞增殖、分化、迁移、凋亡及应激反应中起着重要作用，并与肿瘤、神经退行性疾病和免疫缺陷等重大疾病的发生与发展密切相关。 泛素化作为蛋白翻译后修饰的 …
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