PTEN gene triggers cells to undergo apoptosis and promotes myocardial dysfunction. Several TNF family cytokines are elevated during acute myocardial infarction (AMI). Their role in predicting subsequent prognosis in these setting remains poorly understood.

2019年4月29日 · Patients with acute myocardial infarction had statistically significant increased serum levels of PTEN & TNF-α gene activity. Both markers predict worsening of left ventricular systolic functions, development of heart failure and death.

2007年2月1日 · TNF-α increased PTEN expression at HL-60 cells in a time- and dose-dependent manner, but the response was abolished by disruption of NF-κB with p65 anisense phosphorothioate oligonucleotide...

TNF-α 可以激活促凋亡通路也可激活抗凋亡通路；TNF-α 通过激活 caspase-8 和 -10 诱发凋亡，但也可通过 NF-κB 抑制凋亡，后者诱导抗凋亡基因如 Bcl-2 的表达。

PTEN may play a reversible role in TNFα induced insulin resistance, which has been linked to obesity-associated insulin resistance (IR). Western blots for PTEN and p-Akt were performed on H-411E liver cells incubated with insulin, TNFα, and in selected experiments VO-OHpic vanadium complex in the presence and absence of PTEN siRNA.

Notch1 inhibition significantly repressed TNF-α-induced ASM cell proliferation and migration, while Notch1 overexpression promoted the opposite effect. Moreover, Notch1 inhibition downregulated the expression of Notch-1 intracellular domain (NICD) and Hes1, while upregulated PTEN expression in TNF-α-exposed cells.

2007年2月28日 · TNF-alpha increased PTEN expression at HL-60 cells in a time- and dose-dependent manner, but the response was abolished by disruption of NF-kappaB with p65 antisense phosphorothioate oligonucleotide or pyrrolidine dithiocarbamate.

NF-κB prevents cell death caused by tumor necrosis factor (TNF) and other genotoxic insults by directly inducing antiapoptotic target genes. We report here that the tumor suppressor PTEN, which functions as a negative regulator of phosphatidylinositol (PI)-3 kinase/Akt-mediated cell survival pathway, is down regulated by p65 but not by p50.

2014年6月6日 · There is a TLR4-mediated PTEN/PI3K/AKT/NF-κB signaling pathway in rat hippocampal neurons. This signaling pathway is associated with the activation of neuroinflammatory response. The activation of this pathway results …

2006年11月17日 · The present study showed that PTEN targets the antiapoptotic gene NFκB induced by TNF-α by suppressing several TNF-induced antiapoptotic gene products, thereby confirming our hypothesis that PTEN mediates its effects by modulating NFκB and identifying a function of PTEN in its role as a tumor suppressor.