2024年12月25日 · TNFAIP3 (TNF Alpha Induced Protein 3) is a Protein Coding gene. Diseases associated with TNFAIP3 include Autoinflammatory Syndrome, Familial, Behcet-Like 1 and Familial Behcet-Like Autoinflammatory Syndrome.Among its related pathways are TNF signaling and Metabolism of proteins.Gene Ontology (GO) annotations related to this gene include …

Tumor necrosis factor, alpha-induced protein 3 or A20 is a protein that in humans is encoded by the TNFAIP3 gene. [5] [6] This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF).

肿瘤坏死因子α诱导蛋白 3： 该基因被鉴定为其表达被肿瘤坏死因子 (TNF) 快速诱导的基因。该基因编码的蛋白质是一种锌指蛋白和泛素编辑酶，已被证明可以抑制 NF-kappa B 激活以及 TNF 介导的细胞凋亡。编码的蛋白质具有泛素连接酶和去泛素酶活性，参与细胞因子介导的免疫和炎症反应 …

The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells. Together, the findings indicate a new role of miR-29c in IAV infection and suggest its induction may contribute to counteract the innate immune response.

2012年10月12日 · TNFAIP3 polymorphisms and altered A20 expression have been correlated with therapeutic responses to TNF blockade in the treatment of rheumatoid arthritis, inflammatory bowel disease and...

a20，或肿瘤坏死因子α诱导蛋白3(tnfaip3)，是一种 锌指泛素编辑抗炎酶 ，能够调节免疫反应和细胞凋亡。 A20基因突变体和A20单倍体与几种自身免疫性和自身炎症性疾病有关1-4，包括 类风湿性关节炎 (RA)、 系统性红斑狼疮 (SLE)和 银屑病关节炎 5-7。

TNFAIP3 encodes tumor necrosis factor alpha induced protein 3. TNFAIP3 is a zinc finger protein and ubiquitin-editing enzyme that inhibits NF-kB pathway activation and is also involved in inflammatory response via inhibition of TNF-induced apoptosis [113, 114]. The presence of TNF rapidly increases TNFAIP3 expression in all tissues [115, 116].

The TNFAIP3 gene encodes an ubiquitin-editing enzyme with a critical function in the inhibition of key proinflammatory molecules to negatively regulate inflammation and the immune response (summary by Aeschlimann et al., 2018).

2024年11月14日 · Title: Tumor Necrosis Factor Alpha-Induced Protein-3 Inhibits the Activation of Hepatic Stellate Cells by Regulating the p65 Molecule in the NF-κB Signaling Pathway. Down-regulation of A20 mRNA expression in peripheral blood mononuclear cells from MDS patients.

2018年1月1日 · The 80 kDa protein encoded by TNFAIP3 is the zinc finger protein A20, which has both ubiquitin ligase and deubiquitinase activities. A20, originally discovered in 1990, acts as a central and inducible endogenous negative feedback regulator of the NF-κB signaling pathway, the inappropriate activity of which has been linked to a host of ...