TNO’s patented in vitro gastrointestinal model TIM offers rapid insight into the into the release, solubility and availability for absorption of pharmaceuticals within the gastrointestinal tract. This well-validated and accurate system has a much greater in vivo predictive value than typical in vitro dissolution assays.

The TNO Gastro-Intestinal Model (TIM) is a multi-compartmental model, designed to realistically simulate conditions in the lumen of the gastro-intestinal tract. TIM is successfully used to study the gastro-intestinal behavior of a wide variety of feed, food and pharmaceutical products.

The TNO Gastro-Intestinal Model (TIM) is a multi-compartmental model, designed to realistically simulate conditions in the lumen of the gastro-intestinal tract. TIM is successfully used to study the gastro-intestinal behavior of a wide variety of feed, food and pharmaceutical products.

Using TIM, TNO can conduct a detailed analysis of the release, solubility and bioaccessibility profile of a compound, as well as other physico-chemical properties or pharmaceutical interactions during gastrointestinal transit. Each compartment can be studied separately, measuring even relatively small changes in bioactive components.

The TNO Gastro-Intestinal Model (TIM) is a multi-compartmental model, designed to realistically simulate conditions in the lumen of the gastro-intestinal tract. TIM is successfully used to study the gastro-intestinal behavior of a wide variety of feed, food and pharmaceutical products.

TNO (gastro-) Intestinal Models (“TIM”) is a system of models mimicking the digestive tract. The system was developed by TNO, the Netherlands Organisation for Applied Scientific Research. [1]

The TNO Gastro–Intestinal Model (TIM) is a multi–compartmental model, designed to realistically simulate conditions in the lumen of the gastro–intestinal tract. TIM is successfully used to study the gastro–intestinal behavior of a wide variety of feed, food and pharmaceutical products.

TIM（TNO Intestinal Model）是由荷兰瓦赫宁根大学的Minekus和Havenaar研制的用于药物动态测试的多单元的计算机控制的体外消化模拟系统。 该系统分为两部分，胃、小肠模拟器（TIM-1）和大肠模拟器（TIM-2）。

The TNO computer-controlled, dynamic in vitro gastro-Intestinal Model of the colon (nick-named TIM-2; Fig. 26.1) was developed by TNO some 15 years ago (Minekus et al. 1999). It is based on the TIM-1 system (the TNO in vitro gastro-intestinal model of the stomach and small intestine) that is discussed elsewhere in this book.

tno’s models for gastrointestinal research (tiM) represent the most advanced, patent protected platforms for studying the fate of food and food constituents during digestion in the stomach and small intestine and fermentation in the large intestine. TIM for rapId and accuraTe dIgesTIve ModellIng tiM mimics human or animal digestion