The thyrotropin receptor (TSHR) plays critical roles in thyroid growth and function and in the pathogenesis of several thyroid diseases including Graves’ hyperthyroidism and …

reduced expression of the Tshr gene encoding TSH receptor. TP48 also decreased basal thyroid hormone levels in control rats. Thus, new allosteric antagonists (TPY1) and inverse agonists …

2024年7月22日 · 促甲状腺素受体（Thyrotropin receptor, TSHR）是一种细胞表面糖蛋白受体，属于A类G蛋白偶联受体（GPCRs）超家族的LGR亚家族，并与Gs蛋白相连接。TSHR主要在甲 …

2020年3月1日 · We developed the compound 5-amino-N- (tert-butyl)-4- (4-iodophenyl)-2- (methylthio)thieno [2,3-d]pyrimidine-6-carboxamide (TP48) and showed that it reduces the …

2024年3月14日 · In our laboratory, we developed the compound TP48, a thieno [2,3-d]-pyrimidine derivative endowed with the properties of an inverse agonist, which upon intraperitoneal …

2020年6月1日 · We developed the compound 5-amino- N - (tert -butyl)-4- (4-iodophenyl)-2- (methylthio)thieno [2,3-d]pyrimidine-6-carboxamide (TP48) and showed that it reduces the …

A small molecule TSHR antagonist (ANTAG3) has been shown to inhibit TSI-induced signaling and TSHR activation in the thyroid gland of mice and could thus potentially inhibit TSHR …

人抗tshr单克隆抗体可用于tshr自身抗体(trab)的检测，有助于自身免疫性甲状腺疾病的诊断和治疗。 这些TSHR单抗中，以M22™代替现有检测法中的TSH是目前灵敏度和特异性最高的检测方 …

The thyrotropin receptor (TSHR) plays critical roles in thyroid growth and function and in the pathogenesis of several thyroid diseases including Graves’ hyperthyroidism and …

TP48 also decreased basal thyroid hormone levels in control rats. Thus, new allosteric antagonists (TPY1) and inverse agonists (TP48) of TSH receptor have been developed, which …