2010年10月1日 · Saccharomyces cerevisiae Tpa1, a largely conserved but uncharacterized protein, has been described to associate with a messenger ribonucleoprotein complex located at the 3′ end of mRNAs that contains at least eRF1, eRF3, and Pab1.

2009年12月29日 · Tpa1 (for termination and polyadenylation) from Saccharomyces cerevisiae is a component of a messenger ribonucleoprotein (mRNP) complex at the 3′ untranslated region of mRNAs. It comprises an N-terminal Fe (II)- and 2-oxoglutarate (2OG) dependent dioxygenase domain and a C-terminal domain.

Prolyl hydroxylase; catalyzes oxygen-dependent dihydroxylation of Rps23a/b, a 40S ribosomal decoding center subunit; influences translational termination and regulates translational accuracy; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; disputed role as a oxidative dealkylase repairing DNA methyl-base lesions; poly (rA)-binding protein...

In this report, we show that the Saccharomyces cerevisiae protein Tpa1p (for t ermination and p oly a denylation) influences translation termination efficiency, mRNA poly (A) tail length, and mRNA stability. Tpa1p is encoded by the previously …

Subsequent sequencing of the wild-type and mutant tpa1 confirmed this mutation, thus identified the gene as a candidate gene for TPA1, indicating that TPA1 was a new male sterile gene. This study will lay a foundation for the functional study of TPA1 gene. Key words: rice (Oryza sativa L.), male recessive nuclear infertility, tpa1, fine mapping

Tpa1 (for termination and polyadenylation) from Saccharomyces cerevisiae is a component of a messenger ribonucleoprotein (mRNP) complex at the 3' untranslated region of mRNAs. It comprises an N-terminal Fe (II)- and 2-oxoglutarate (2OG) dependent dioxygenase domain and a C-terminal domain.

SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and …

Results: Tpa1 is a Fe(II)/2OG-dependent dioxygenase and mediates alkyl-base repair in Saccharomyces cerevisiae, and deleting TPA1 with DNA glycosylase MAG1 had a synergistic effect on the susceptibility to methylation-induced toxicity. Conclusion: Tpa1 protein plays a crucial role in DNA alkylation repair. Saccharomyces cerevisiae.

2010年4月1日 · Tpa1 (for termination and polyadenylation) from Saccharomyces cerevisiae is a component of a messenger ribonucleoprotein (mRNP) complex at the 3′ untranslated region of mRNAs. It comprises an...

2014年12月12日 · Results: Tpa1 is a Fe (II)/2OG-dependent dioxygenase and mediates alkyl-base repair in Saccharomyces cerevisiae, and deleting TPA1 with DNA glycosylase MAG1 had a synergistic effect on the susceptibility to methylation-induced toxicity. Conclusion: Tpa1 protein plays a crucial role in DNA alkylation repair.