Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates. In humans, TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression in the raphe nucleus of the midbrain.

Duke大学医学中心的分子生物学教授James B. Duke等又在动物试验中观察到，一种名为色氨酸羟化酶-2 (TPH2)的特殊蛋白会影响小白鼠脑组织中的 5-羟色胺 正常含量，而后者对于机体的精神健康至关重要：其含量的下降意味着脑神经细胞之间的相互联系出现异常，而这 ...

2024年12月25日 · TPH2 (Tryptophan Hydroxylase 2) is a Protein Coding gene. Diseases associated with TPH2 include Major Depressive Disorder and Depressive Disorder. Among its related pathways are superpathway of tryptophan utilization and …

人类的两个TPH基因分别位于 11号染色体 和 12号染色体 上，它们编码着不同却同源的酶—— TPH1 及 TPH2，这两种基因的序列一致性达71%。 [4] TPH1主要 表达 在分泌5-羟色胺的 组织 中，如 皮肤 、 肠道 、 松果体 以及 中枢神经系统 中。 TPH2则仅在 神经细胞 中表达，且其于中枢神经系统中的表达量较TPH1大。 ^ McKinney J, Teigen K, Frøystein NA, Salaün C, Knappskog PM, Haavik J, Martínez A. Conformation of the substrate and pterin cofactor bound to human …

The pharmacological significance of TPH2 lies in that: 1) TPH2 is a promising target for the development of new therapeutic strategies in neuropsychiatric disorders; and 2) TPH2 gene expression or function affects drug response.

Introduction: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme of serotonin (5-HT) synthesis in the brain. Some polymorphic variants of the human Tph2 gene are associated with psychiatric disorders.

2023年6月1日 · Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in serotonin biosynthesis in the brain. Consequently, regulation of TPH2 is relevant for serotonin-related diseases, yet the regulatory mechanism of TPH2 is poorly understood and structural and dynamical insights are missing.

2018年7月24日 · TPH2主要表达于脑干中缝神经元和肠道肌肠层神经元，被认为是5-HT中枢神经递质池的来源；而大多数血液中的5-HTP是由胃肠道表达TPH 1的ECs合成的，储存在血栓性细胞密集颗粒中，在活化部位的血小板释放发挥其调节激素作用。 TPH 1也存在于其他外周组织，如胰腺、脂肪和肺，松果体等。 过去，针对5-HT系统的药物仅仅针对5-HT转运体和受体，主要用于治疗抑郁症、精神病和偏头痛等中枢症状。 然而，由于5-HT系统二重性的发现，使其成为了一 …

2025年2月8日 · TPH2 expression is regulated by DNA methylation of the TPH2 promoter region in patients with major depressive disorder. results provide evidence for an association between the rs7305115 polymorphism of the TPH-2 gene and suicidal behavior in a Mexican population.

该基因编码依赖蝶呤的芳香酸羟化酶家族的一个成员。 编码的蛋白质催化血清素生物合成的第一步和限速步骤，血清素是一种重要的激素和神经递质。 该基因的突变可能与双相情感障碍和重度抑郁症等精神疾病有关。 [RefSeq 提供，2016 年 2 月] This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter.