We now report that TRP-2 (tyrosinase related protein-2), which maps to and is mutated at the slaty locus in mice, encodes a protein with DOPAchrome tautomerase activity.

We now report that TRP-2 (tyrosinase related protein-2), which maps to and is mutated at the slaty locus in mice, encodes a protein with DOPAchrome tautomerase activity. 哺乳动物黑色素的产生需要酪氨酸酶，一种将氨基酸酪氨酸羟基化为多巴（3,4-二羟基苯丙氨酸）的酶，从而允许合成生物聚合物所需的级联反应。 然而，在酪氨酸酶的作用下，还有其他调节步骤可以调节产生的黑色素的数量和质量。

2019年6月1日 · Tyrosinase-Related Protein 2 (TRP2) is an enzyme involved in melanogenesis, that also exerts proliferative, anti-apoptotic and immunogenic functions in melanoma cells. TRP2 transcription is regulated by the melanocytic master transcription factor MITF.

In this paper we identify a normal tissue differentiation antigen, tyrosinaserelated protein 2 (TRP-2), expressed by the murine B16 melanoma which was found by screening a cDNA library from B16 with tumor-reactive cytotoxic T lymphocytes (CTL).

We now report that TRP-2 (tyrosinase related protein-2), which maps to and. with DOPAchrome tautomerase activity. produced (reviewed in Hearing and Tsukamoto, 1991 and Pawelek, 1991). Tyrosinase (EC 1.14.18.1) remains the critical enzyme to the pathway since it catalyzes the initial.

Tyrosinase-related protein-2 (TRP-2) is another melanocyte differentiation antigen. Functionally, TRP-2 is a dopachrome-tautomerase (DCT), modifying the structure and composition of melanin 9 – 11. Different from tyrosinase, the absence of TRP-2 does not result in lack of pigmentation but rather modifies the color of pigmentation.

1992年3月1日 · We now report that TRP-2 (tyrosinase related protein-2), which maps to and is mutated at the slaty locus in mice, encodes a protein with DOPAchrome tautomerase activity. Synthesis and...

2024年3月11日 · Tyrosinase-related Protein 2 (TRP-2) (181-188) 是 TRP2 蛋白的 181-188 序列短肽,是 anti-B16 CTLs 识别 TRP-2 的主要反应表位。Tyrosinase-related Protein 2 (TRP-2) (181-188) 与 MHC I 类 H2-Kb 结合基序一致。 相关类别

Using a peptide from the melanocyte differentiation antigen tyrosinase-related protein (TRP2) 2 we could show that vaccination with liposome-encapsulated peptide in combination with oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) as adjuvant leads to the induction of tumor cell-specific cytotoxic T cells.

2003年8月28日 · One of these antigens, that is, TRP-2, expressed by a DNA vaccine induces protective T-cell-mediated immunity to a subsequent peripheral or intracerebral challenge with an otherwise fatal dose of...

2020年2月11日 · TRP2 belongs to the melanocyte differentiation antigens and has been implicated as a target for immunotherapy of human as well as murine melanoma. Studies show that this TRP2 derived peptide can bind to mouse and human MHC class I molecules.

We now report that TRP-2 (tyrosinase related protein-2), which maps to and is mutated at the slaty locus in mice, encodes a protein with DOPAchrome tautomerase activity.

Tyrosinase-related protein-2 (TRP-2) is a non-mutated melanocyte differentiation antigen. The TRP-2-recognizing CD8 (+) T cells can evoke immune responses to melanoma in both humans and mice. Developing epitopes with amino acid replacements in their sequences might improve the low immunogenicity against this 'self' tumor antigen.

1992年2月1日 · We show that the TRP‐2 of slaty mice has a single amino acid difference from wild‐type TRP‐2; a substitution of glutamine for arginine in the first copper binding site. TRP‐2 is the much sought melanogenic enzyme DOPAchrome tautomerase (DT), which catalyses the conversion of DOPAchrome to 5,6,dihydroxyindole‐2‐carboxylic acid.

2014年4月1日 · TRP-2 is a membrane-bound melanosomal enzyme involved in melanin biosynthesis also known as a melanoma differentiation antigen expressed in normal melanocytes, melanomas, normal retinal tissue and brain [8]. TRP-2 was identified by screening a tumor cDNA library with a T cell line exhibiting an in vivo antitumor activity. This finding ...

Little is known about tyrosinase-related protein 2 (TRP-2, or dopachrome tautomerase/DCT) another melanocyte differentiation antigen, which is an enzymatic component of melanogenesis. We identified a commercial reagent to TRP-2, monoclonal antibody (mAb) C-9 and undertook a comprehensive analysis to assess its specificity and usefulness for ...

TRP-2 is the much sought melanogenic enzyme DOPAchrome tautomerase (DT), which catalyses the conversion of DOPAchrome to 5,6,dihydroxyindole-2-carboxylic acid. Extracts from mice homozygous for the slaty mutation have a 3-fold or more reduction in DT activity, indicating that TRP-2/DT is encoded at the slaty locus, and the missense mutation ...

2019年11月1日 · In this study, we designed a mannose-modified poly (β-amino ester)-stearylamine (man-PBAE-S), to co-deliver the melanoma-associated antigen peptide Trp-2 and the immune adjuvant monophosphoryl lipid A (MPLA, a TLR4 agonist) as nano-vaccines (T/M@mPS) to DCs, which presented antigens to T cells, induced their activation and proliferation, and fur...

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