The transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene.

The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel. Nonetheless, ...

Because TRPV1 functions as a molecular integrator for multiple types of sensory input, in this chapter we will explore the molecular mechanisms underlying the activation and modulation of this channel.

The transient receptor potential (TRP) family comprises a diverse group of cation channels that regulate a variety of intracellular signaling pathways. The TRPV1 (vanilloid 1) channel is best known for its role in nociception and sensory ...

2024年12月25日 · TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a Protein Coding gene. Diseases associated with TRPV1 include Cystinosis, Nephropathic and Pulpitis. Among its related pathways are Ion channel transport and CREB Pathway.

The TRPV1 (vanilloid 1) channel is best known for its role in nociception and sensory transmission. First studied in the dorsal root ganglia as the receptor for capsaicin, TRPV1 is now recognized to have a broader distribution and function within the central nervous system (CNS).

Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely expressed in sensory nerve fibers and nonneuronal cells, ...

2013年12月4日 · Comparison of the closed and open structures suggests that TRPV1 has a unique two-gate mechanism of channel activation.

TRPV1 is a well-characterised channel expressed by a subset of peripheral sensory neurons involved in pain sensation and also at a number of other neuronal and non-neuronal sites in the mammalian body. Functionally, TRPV1 acts as a sensor for noxious heat (greater than ~42 °C).

2017年5月10日 · Nature Communications - TRPV1 is known to be expressed in peripheral structures and the spinal cord, especially for pain processing. Here the authors show that in the brain, in particular the...