Transient receptor potential cation channel subfamily V member 4 is an ion channel protein that in humans is encoded by the TRPV4 gene.

TRPV4 as a Therapeutic Target in Neurological Disease. The therapeutic potential of TRPV4 modulation is a rapidly evolving field due to the key role of TRPV4 in various diseases. We explore the molecular mechanisms through which TRPV4 contributes to disease pathogenesis in conditions such as inflammation, neuropathic diseases (e.g., Alzheimer ...

2019年6月24日 · We herein reviewed the research focus on the relationship between TRPV4 and cancer, also explored the mechanism of TRPV4-mediated oncogenesis and the strategy that target TRPV4 for tumor...

2024年5月29日 · 瞬时感受器电位香草酸受体4（Transient Receptor Potential Vanilloid 4，TRPV4）是瞬时受体电位离子通道家族的成员之一，属于非选择性阳离子通道。 TRPV4广泛分布于大脑、心脏、肝脏、肺部、肾脏、胰腺、卵巢、骨组织以及皮肤表面，可以被机械刺激、低渗透压、温度等 ...

2024年12月25日 · TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a Protein Coding gene. Diseases associated with TRPV4 include Metatropic Dysplasia and Hereditary Motor And Sensory Neuropathy, Type Iic .

TRPV4, the fourth member of the vanilloid subfamily of TRP channels, is a calcium-permeable cation channel that is detectable in both sensory and nonsensory cells. It has been shown to be widely expressed, including in kidneys, lungs, hearts, brains, endothelial cells, and dorsal root and trigeminal sensory ganglia.

The importance of these molecules is exemplified by the variety of physiological roles they play. Perhaps, the most extensively studied member of this family is the TRPV1 ion channel; nonetheless, the activity of TRPV4 has been associated to several physio and pathophysiological processes, and its dysfunction can lead to severe consequences.

2023年6月23日 · Overall, the TRPV4-RhoA complex can serve as a link between the rapid and slow responses to mechanical stretch: TRPV4 opening mediates fast calcium influx that causes sustained RhoA activation...

该研究描述了TRPV4(transient receptor potential vanilloid 4)是瞬时受体电位离子通道的C-末端的一段二十个氨基酸作为“折叠识别区域”在通道蛋白成熟、膜表面表达和功能的动态调节上发挥重要的作用。

Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol 2: 695-702, 2000) and Liedtke (Cell 103: 525-535, 2000). TRPV4 is now recognized as being a polymodal ionotropic rece …