Comparison Between Thyroid Stimulating Immunoglobulin and …
Thyroid stimulating immunoglobulins (TSI) is a relatively new method for assessing TSH-receptor antibodies. The aim of this study was to investigate the role of TSI in the management of GO.
甲亢诊断的新指标——TSI-南方检验医学网
2021年12月28日 · TSI 的生物效应类似促甲状腺激素（TSH），与表达 于甲状腺滤泡上皮细胞膜上的 TSH 受体 (TSHR)结合，激活腺苷酸环化酶信号系统，刺激滤 泡上皮细胞增生，甲状腺弥 …
Clinical Utility of TSH Receptor Antibodies - PMC
What is the best TRAb test for diagnosing GD? Should we be using the thyroid-stimulating Ig (TSI), TSH-binding inhibiting (TBI) Ig, or the new bioassays? Are TRAb levels predictive of …
immunoglobulins (TSI) bind to the TSH receptor (TSHR) and mimic TSH stimulation of the thyroid gland.1 Because TSI induced thyroid hormone secretion is not controlled by negative …
促甲状腺激素受体抗体的检测及应用进展 - 国际内分泌代谢杂志
促甲状腺激素(thyroid stimulating hormone，TSH)受体抗体(TSH receptor antibody，TRAb)在自身免疫性甲状腺病患者体内特异性存在，其中甲状腺刺激性抗体(thyroid stimulating …
Thyrotropin-Blocking Autoantibodies and Thyroid-Stimulating ...
Thyrotropin receptor (TSHR) antibodies that stimulate the thyroid (TSAb) cause Graves' hyperthyroidism and TSHR antibodies which block thyrotropin action (TBAb) are occasionally …
Autoantibody mimicry of hormone action at the thyrotropin receptor
2022年8月8日 · Persistent direct activation of the TSHR by TSI overcomes the physiological hypothalamic–pituitary–thyroid negative feedback loop, leading to elevated thyroid hormones …
全面解析促甲状腺素受体（TSHR）：甲状腺疾病的诊断与治疗新 …
2024年7月22日 · 促甲状腺素受体（Thyrotropin receptor, TSHR）是一种细胞表面糖蛋白受体，属于A类G蛋白偶联受体（GPCRs）超家族的LGR亚家族，并与Gs蛋白相连接。TSHR主要在甲 …
促甲状腺素受体抗体（TRAb）的生物学功能及临床诊断意义
促甲状腺素受体抗体英文缩写为trab或tshr抗体，是甲状腺b淋巴细胞针对tshr产生的一种自身抗体。 TRAb是由于基因突变等原因导致人体内促甲状腺激素受体（TSHR）结构发生改 …
Structure and activation of the TSH receptor transmembrane …
2016年12月5日 · The thyroid-stimulating hormone receptor (TSHR) is the target autoantigen for TSHR-stimulating autoantibodies in Graves’ disease. The TSHR is composed of: a leucine …