
Thymic stromal lymphopoietin - Wikipedia
Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-2-like cytokine, alarmin, and growth factor involved in numerous physiological and pathological processes, primarily those of the …
【靶点聚焦】——TSLP/TSLP R:炎症、癌症药物开发重要靶点
2023年4月27日 · TSLP(胸腺间质淋巴生成素, Thymic stromal lymphopoietin) 是一种与IL-7互为远距离旁系同源的,归属于短链四α螺旋束Ⅰ型IL-2家族的多效性细胞因子。 主要由上皮细胞 …
Role of thymic stromal lymphopoietin in allergy and beyond
2022年6月1日 · TSLP promotes and amplifies T helper 2 (T H 2)-type immunity, which enhances the immune response to antigens or allergens through both adaptive and innate immune …
TSLP胸腺基质淋巴细胞生成素的相关机制综述 - 知乎
TSLP 作为上皮细胞分泌的一种重要的过敏因子 ,通过与局部浸润的DC细胞和T细胞的相互作用 ,诱导机体 Th2反应 的发生,另外TSLP还可以通过对Th1通路的抑制作用 ,使得机体的炎症 …
什么是胸腺基质淋巴细胞生成素(TSLP)? - 知乎
胸腺基质淋巴细胞生成素(tslp) 起着关键作用。tslp可以驱动下游t2细胞因子的释放(包括il-4、il-5和il-13等),从而导致哮喘及其他的炎症症状。 TSLP可以驱动下游T2细胞因子的释放(包括IL-4 …
Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the …
TSLP, mainly produced in response to pathogenic stimuli by lung and intestinal epithelial cells and skin keratinocytes, induces complex immune responses at barrier surface level by activation of …
TSLP: from allergy to cancer - Nature Immunology
2019年11月19日 · The mRNA for the second isoform, referred to as ‘short-form TSLP’ (sfTSLP), was shown to be initiated from an internal promoter in intron 2 of TSLP 15.
Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the
2023年8月12日 · The emergence of lfTSLP as a central orchestrator of type 2 responses capable of initiation of inflammation and allergy has preferentially positioned a new therapeutic …
The discovery of human TSLP as a critical epithelial cytokine in type 2 ...
2020年7月2日 · Using such an approach, mouse thymic stromal lymphopoietin (TSLP) was identified from a thymic stromal cell line that produces a factor supporting the early stages...
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