2010年11月19日 · Total Therapy 2 (TT2) for Multiple Myeloma (MM): Contributions to Survival Outcomes of Dosing of Thalidomide (T), Dexamethasone (D) and Interferon (I) Maintenance Components. Frits van Rhee, MD, PhD ,

2006年4月1日 · Patients with myeloma, treated on the thalidomide arm of total therapy 2 (TT2), had a higher complete response (CR) rate and improved event-free survival (EFS) but not overall survival (OS).

2012年6月18日 · TT2 (n =668) was a phase III trial that randomized patients to an experimental arm with thalidomide added from the outset and continuing throughout consolidation and maintenance.

2014年11月13日 · The genomic chaos and resulting resistance to apoptosis of myeloma, long considered an obstacle to cure, formed the basis of Total Therapy (TT) program. The TT approach uses all myeloma-active drugs upfront to target drug-resistant subclones during initial treatment to prevent later relapse.

2014年12月6日 · Six newly diagnosed transplant-ineligible high-risk patients were offered an extended 28-day course of low-dose metronomic therapy with bortezomib, thalidomide, dexamethasone and continuous infusions of doxorubicin and cisplatin, to which were added arsenic trioxide and vincristine infusions.

2015年11月3日 · In order to determine whether novel agents had different effects within molecular subgroups, we compared the outcomes of patients treated without novel drugs (TT2−) with patients treated with...

TT2's major advance vis-à-vis TT1 pertained to the subgroup without cytogenetic abnormalities (CA), supporting the role of post-transplant consolidation therapy, whereas the improved survival of the CA subgroup on the experimental versus control arm of …

2023年5月31日 · TT approach uses all MM-active drugs upfront to target drug-resistant subclones during initial treatment to prevent later relapse. We report the longest follow up of MM trials (TT1 (NCT00580372), TT2 (NCT00083551), TT3a (NCT00081939) and TT3b (NCT00572169)) reported to date with RSRs to assess for curability.

2024年5月22日 · Using an established animal model for tinnitus induced by noise exposure, we developed a new nasal formulation for NMDP (GW-TT2) to reduce its systemic side effects, increase its brain delivery, and improve patients’ experience with the use of this drug.

Using an established animal model for tinnitus induced by noise exposure, we developed a new nasal formulation for NMDP (GW-TT2) to reduce its systemic side effects, increase its brain delivery, and improve patients’ experience with the use of this drug.