2024年12月25日 · TTK (TTK Protein Kinase) is a Protein Coding gene. Diseases associated with TTK include Pancreatic Cancer and Lung Cancer. Among its related pathways are Cell cycle and DNA Damage. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

Dual specificity protein kinase TTK also known as Mps1 is an enzyme that in humans is encoded by the TTK gene. [5] [6]

2014年8月19日 · We show that the dual specificity kinase TTK (also known as Mps1), is strongly overexpressed in human PDAC. Functionally, cell proliferation was significantly attenuated following TTK...

2018年9月12日 · In this study, we examined the role of TTK in triple negative breast cancer (TNBC), and found that higher TTK expression correlated with mesenchymal and proliferative phenotypes in TNBC cells.

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication.

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication.

The TTK gene on 6q14.1 encodes a dual-specificity protein kinase (hMps1), a key spindle assembly checkpoint protein that regulates the proper chromosomal alignment and segregation during mitosis. Data show that Thr/Tyr kinase (TTK)/monopolar spindle 1 kinase (Mps-1) is overexpressed in malignant mesothelioma (MM) and that its expression ...

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication.

2016年9月14日 · This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication.

TTK has 7,169 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or …